尿毒清颗粒治疗慢性肾衰竭研究概况  

Overview research of uremic ulearance granule treating chronic renal failure

作　　者：孟宪杰[1] 万毅刚[2] 魏晴雪[1] 陈好利[1] 史喜苗[1] 黄燕如[1] 姚建 

机构地区：[1]南京中医药大学中西医结合鼓楼临床医学院,江苏南京210029 [2]南京大学医学院附属鼓楼医院中医科,江苏南京210008 [3]Department of Molecular Signaling University of Yamanashi, Yamanashi, Japan 409-3898

出　　处：《中国中药杂志》2013年第21期3651-3655,共5页China Journal of Chinese Materia Medica

基　　金：南京市卫生青年人才培养工程项目;江苏省中医药局科技项目(LZ11116)

摘　　要：尿毒清颗粒(uremic clearance granule,UCG)的主要生物活性成分包括异黄酮、大黄素、黄芪甲苷、芍药苷、丹酚酸A等。在临床上,UCG可以改善慢性肾衰竭(chronic renal failure,CRF)患者的肾功能,并减少CRF相关并发症;其药理机制包括抑制转化生长因子(transforming growth factor,TGF)-β1表达,减轻足细胞损伤,抑制肾小管上皮细胞转分化,改善微炎症状态,抑制氧化应激,减轻胰岛素抵抗等。The effective bioactivity compositions of uremic clearance granul（UCG）include isoflavonoids,emodin,astragaloside,paeoniflorin,salvianolic acid A,and so on. The effects of UCG treating chronic renal failure（CRF）in clinical pharmacodynamics mainly refer to improve renal function and the complications of CRF. The mechanisms involved in vivo basically include depressing transforming growth factor（TGF）-β1 over-expression,lessening podocyte injury,inhibiting tubular epithelial myofibroblast transdifferentiation,ameliorating microinflammation status,retarding oxidative stress,and alleviating insulin resistance.keywords：uremic clearance granul

关 键 词：尿毒清颗粒 慢性肾衰竭 药理机制 

分 类 号：R277.5[医药卫生—中医学]