芳基-α-氯代-α-羰基肟的合成研究  

Study on the Synthesis of α-Chloro-α-carbonyl Oxime

作　　者：龚亚红[1] 姬文娟[2] 连昕[1] 王宇光[1] 朱冰春[2] 

机构地区：[1]浙江工业大学生环学院,浙江杭州310014 [2]浙江省化工研究院,浙江杭州310023

出　　处：《精细化工中间体》2013年第4期11-13,38,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金项目(21202151);"十二五"国家科技支撑计划项目(2011BAE06B01-20);浙江省重点科技创新团队项目(2010R50018)

摘　　要：以芳基乙酮为原料,亚硝酸异戊酯做亚硝化试剂,通入氯化氢气体,合成了9个α-氯代-α-羰基肟类化合物。反应时间可由传统方法的5~6 h缩短至2~3 h,目标产物收率由30%提高至80%。化合物结构经1H NMR和IR确认。Nine novel a-chloro-a-carbonyl oximes were synthesized starting from acetophenone, isoamyl nitrite and anhydrous hydrogen chloride. Comparing with conventional method, this route can reduce the reaction time from 5~6 hours to 2-3 hours, and increase the yield of the target products from 30% to 80%. The structures of the compounds were confirmed by IH NMR and IR spectra. Key words： a-chloro-a-carbonyl oxime ; synthesis ; characterization ; isoxazoline

关 键 词：α-氯代-α-羰基肟 合成 结构表征 异噁唑啉 

分 类 号：TQ252.4[化学工程—有机化工]