药物夫西地酸钠对血清胆汁酸测定的影响  

Effects of Sodium Fusidate on total blile acid

作　　者：梁淑新[1] 王淑仙[1] 郝婉姣 

机构地区：[1]河北大学附属医院检验科,河北保定071000

出　　处：《医学研究与教育》2013年第5期24-27,共4页Medical Research and Education

摘　　要：目的探讨药物夫西地酸钠对血清胆汁酸(TBA)检验结果的影响。方法采用酶循环法测定血清中的TBA含量。以蒸馏水为对照,分别测定血清、夫西地酸钠和蒸馏水混合溶液及其不同浓度的稀释液、夫西地酸钠和血清混合溶液及其不同浓度的稀释液中的TBA含量,每个样品重复3次。结果血清TBA浓度为4.4μmol/L;夫西地酸钠蒸馏水混合溶液及其2、4、8、16倍稀释液的TBA平均浓度分别为226.53、130.42、77.12、40.78、21.47μmol/L;夫西地酸钠血清溶液及其2、4、8、16倍稀释液的TBA平均浓度分别为233.17、138.82、85.47、47.91、25.58μmol/L。结论实验证明夫西地酸钠可严重影响血清中TBA含量的测定,使检验结果显著升高。因此对需要检测肝功能的患者,建议检测前禁止服用夫西地酸钠。Objective To investigate the effects of Sodium Fusidate on detections of serium total blile acid（TBA）. Methods Serium TBA was detected by using the circulating enzymatic method. Distilled water was treated as a control, the amount of TBA was analyzed in different solutions as follows： in serium, in the mixture of Sodium Fusidate and distilled water and in its different concentrations respectively; and in the mixture of Sodium Fusidate and serium and in its different concentrations respectively. Each solution was analyzed triplicatedly. Results The average Serium TBA was 4.4 μmol/L. However, the average amount of TBA in the mixture of Sodium Fusidate and distilled water and in its dilutions of 2, 4, 8, 16 times were 226.53, 130.42, 77.12, 40.78, 21.47 μmol/L respectively. Correspondendly, the average results of Sodium Fusidate serium mixture and its 2, 4, 8, 16 times dilutions were 233.17, 138.82, 85.47, 47.91, 25.58 μmol/L respectively. Conclusion The assays desmontrate that Sodium Fusidate could severely affect the detection of serium TBA and give rise to significant increases. Therefore, it is suggested that those patients who need to know their liver functions should stop taking Sodium Fusidate before doing the tests.

关 键 词：夫地西酸钠 血清胆汁酸 酶循环法 

分 类 号：R9[医药卫生—药学]