HPLC-MS法测定Beagle犬血浆中槐果碱的浓度及其药代动力学研究  

HPLC-MS for the Determination of Sophocarpine in Beagle Dog Plasma and Its Application in the Pharmacokinetic Study

作　　者：董海娟[1] 盛龙生[2] 王广基[2] 马仁玲[1] 

机构地区：[1]中国药科大学药物质量与安全预警教育部重点实验室,南京210009 [2]中国药科大学药物代谢动力学重点实验室,南京210009

出　　处：《药学与临床研究》2013年第5期513-515,共3页Pharmaceutical and Clinical Research

摘　　要：应用本研究组已经建立的LC-MS方法,采用双周期自身交叉设计研究Beagle犬灌胃、静注给予槐果碱后的药代动力学,结果显示两种给药方式下槐果碱的药时曲线均符合二房室模型,消除半衰期基本一致,分别为(2.75±0.17)h和(2.28±0.10)h;研究还表明,该药吸收快、体内分布快,Beagle犬灌胃的绝对生物利用度为45.28%。An LC-MS method established and reported by our research group was used to investigate the pharmacokinetics of sophocarpine according to a two-period crossover design in Beagle dogs after intragastric and intravenous administration.The results showed that the drug disposition through both routs conformed to the two-compartment model,the elimination half-life for intragastric and intravenous administration were （2.75±0.17） h and （2.28±0.10） h respectively.The results indicated that sophocarpine was absorbed and distributed quickly in Beagle dogs.The absolute bioavailability of sophocarpine with intragastric administration was 45.28％.

关 键 词：槐果碱 HPLC-MS BEAGLE犬 血浆 

分 类 号：R969.1[医药卫生—药理学]