斑马鱼胚胎左右不对称发育的研究现状与展望  

Present Status and Prospect of Research on Left- Right Asymmetry Development of Embryo in Zebrafish

作　　者：邹霞[1] 李筠[1] 周建峰[1] 

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,山东青岛266003

出　　处：《山东农业科学》2013年第10期135-139,共5页Shandong Agricultural Sciences

基　　金：国家重点基础研究发展计划("973"计划)项目"发育关键信号通路的新介导因子对胚层诱导和分化的调控作用(2011CB943800-G)"

摘　　要：脊椎动物单从体表特征来看,一般呈两侧对称,但是大多数内脏器官和系统在体内多为不对称分布,而且这种分布方式对于器官或系统功能的行使是必须的。左右不对称发育起始于胚胎时期,打破了机体两侧对称的发育模式,在不同脊椎动物中均很保守。目前利用斑马鱼为模式生物,对胚胎左右不对称发育的研究已经取得了一系列进展,包括临时器官Kupffer’s囊泡的形成、左右不对称发育信号在侧板中胚层中的传递、器官不对称分布等。本文就近年来以斑马鱼为模式生物对胚胎左右不对称发育机制研究的进展进行综述。From the body surface characters, vertebrates were generally bilateral symmetry; but most of internal organs and systems were left - right （LR） asymmetry, which was necessary for their funetionating. The LR asymmetry occurs dunng embryonic development. It is one of conserved mechanisms among verte- brates. Recent researches using zebrafish as a model organism have provided many insights into how the Kupffer＇ s vesicle organizer region generates, how the Kupffer＇ s vesicle relays LR asymmetry information to the lateral plate mesoderm, and how the organs distribute asymmetrically. In this paper, the recent advances in research of LR asymmetry development of embryo in zebrafish were reviewed.

关 键 词：左右不对称发育 Kupffer’s囊泡 侧板中胚层 细胞信号通路 正反馈调节 

分 类 号：Q959.468.031[生物学—动物学]