超滤法对清喉颗粒除杂效果的研究  

A Study of the Impurity-Removing Effect of the Ultrafiltration Technique on Throat-Cleansing Powder

作　　者：蒲维维[1] 杨万政[2] 王捷 

机构地区：[1]中国气象局北京城市气象研究所,北京100089 [2]中央民族大学生命与环境科学学院,北京100081 [3]内蒙古宇航人高技术产业有限责任公司,内蒙古呼和浩特011517

出　　处：《内蒙古石油化工》2013年第15期4-6,共3页Inner Mongolia Petrochemical Industry

摘　　要：目的:考察超滤技术对清喉颗粒的除杂效果。方法:以绿原酸、总黄酮、牛蒡子苷保留率及固形物减少率为指标,对膜分子量、药液比、温度、加水量等4因素进行考察。结论:确定超滤工艺为:药液比为1∶16(g/ml)的药液,在40℃条件下进行超滤(超滤膜的截留分子量为20万),在超滤过程中补加5倍量水。采用超滤技术对药液进行除杂,能够有效去除药液中的热原,提高药液澄明度,较大程度保留有效成分。Objective：To study the impurity-removing effect of the ultrafiltration technique on throat-cleansing powder.Method：With the retention rate of chlorogenic acid,total flavonoids,and arctiin,and solids reduction rate set as indices,membrane molecular weight,solute-to-solvent ratio,temperature and the amount of water added are examined.Conclusion：The optimal ultrafiltration technique is determined to be：solute-to-solvent ratio at 1：16（g/ml）;ultrafiltration conducted at 40°C（molecular weight cut-off at 2×105）;5times as much as the original amount of water added in.The ultrafiltration method proves effective in removing the pyrogens in the solution,improving its transparency,and retaining the effective ingredients.

关 键 词：超滤 绿原酸 总黄酮 牛蒡子苷 

分 类 号：TQ461[化学工程—制药化工]