肺炎支原体肺炎患儿血清白介素18、TNF-α、TGF-β1的临床意义  

Clinical significance of serum interleukin-18,TNF-alpha and TGF-beta1 in patients with mycoplasma pneumonia

作　　者：陆彩霞 李筠 彭德伟 姚泽忠 

机构地区：[1]上海市闵行区中心医院儿科,上海201199

出　　处：《临床肺科杂志》2013年第12期2199-2201,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的 探讨肺炎支原体肺炎（MP）患儿血清白介素18、肿瘤坏死因子（TNF-α）、转化生长因子（TGF-β1）水平及其临床意义.方法 采集2011年5月～2012年12月入住我院的60例肺炎支原体患儿与40例健康儿的血清,采用酶联免疫吸附法测定其血清IL-18、TNF-α及TGF-β1,比较MP急性期及恢复期与对照组、MP重症患者与轻症患者急性期、MP重症患者与轻症患者恢复期上述指标的水平.结果 MP恢复期及急性期与对照组血清IL-18、TNF-α及TGF-β1水平相比,差异均具有统计学意义（P＜0.05）,且MP急性期与恢复期相比,差异具有统计学意义（P＜0.05）;MP重症患者与轻症患者急性期血清各指标差异具有统计学意义（P＜0.05）;MP重症患者与轻症患者恢复期血清各指标差异具有统计学意义（P＜0.05）.结论 健康儿与MP患儿血清IL-18、TNF-α、TGF-β1具有明显差异,且在不同发病期、病情轻重方面也具有明显差异,对于MP的临床诊断具有重要意义.Objective To investigate the level of serum interleukin 18 （IL-18）, tumor necrosis factor （TNF-a）, and transfor- ming growth factor （TGF-β1） in patients with mycoplasma pneumonia （MP） and its clinical significance. Methods The study selected 60 MP children as the observation group and and 40 healthy children as the control group. Their levels of serum IL-18, TNF-α and TGF- β1 were detected and determined by enzyme-linked immunosorbent. Results There were statistical differences on the levels of IL-18, TNF-α and TGF- β1 between MP patients at recovery period and acute phase and the control group （ P 〈 0. 05 ）. There were significant differences on the levels of IL-18, TNF-α and TGF-β1 between patients with severe MP and mild MP （ P 〈 0. 05 ）. Conclusion There is a significantly statistical difference on the levels of serum IL-18, TNF-α and TGF-β1 between healthy children and children with MP, and there exists obvious difference on children at different stages and severity, which can provide important basis for the clinical diagnosis of MP.

关 键 词：肺炎支原体肺炎(MP) 白介素18(IL-18) 肿瘤坏死因子(TNF-α) 转化生长因子(TGF-β1) 

分 类 号：R725.6[医药卫生—儿科]