β_3肾上腺素能受体应用的研究进展  

Research Progress in Application of Beta 3-Adrenoreceptor

作　　者：安慧玲[1] 杨君[1] 陈枚洁[2] 陈哲[3] 缪国斌[4] 

机构地区：[1]首都医科大学附属北京朝阳医院综合科,北京100020 [2]首都医科大学附属北京朝阳医院第三临床医学院基地班,北京100020 [3]首都医科大学附属北京朝阳医院内分泌科,北京100020 [4]首都医科大学附属北京朝阳医院西区心内科,北京100020

出　　处：《医学综述》2013年第19期3470-3474,共5页Medical Recapitulate

基　　金：北京市自然科学基金(7122073);首都医科大学临床-基础合作基金(11 JL-L06);本科生科研创新计划(xsky2012073)

摘　　要：β3肾上腺素能受体(β3-AR)是继β1-AR、β2-AR后发现的又一β肾上腺素受体。β3-AR广泛分布于脂肪组织、心脏、血管、消化系统、泌尿生殖系统和脑组织等。β3-AR属G蛋白偶联家族,可通过结合Gi和Gs发挥生理、病理作用。在脂肪组织中,β3-AR介导脂肪分解、促进能量代谢及产热效应;而在心血管系统中,β3-AR可介导心肌负性变力效应及血管平滑肌舒张作用。目前,对于β3-AR在人体不同组织器官的生理病理过程开展了广泛的研究,但仍有许多问题尚未解决。β-Adreneptors were originally classified into two dif（rent subtypes, βt -AR and 132-AR, β-AR was tbund recently. 133-AR are located not only on the membrane of adipose tissue,but also exist in human heart,vessel, digestion system, urogenital system, brain and so on. 133-AR belong to the G protein coupling family, play the physiological pathology effect through the combination with Gi and Gs. In fat tissue, 133-AR mediates adipose decomposition, promotes energy metabolism and produces heat effect ; in the cardio- vascular system, 133 -AR mediates myocardial negative inotropic, effects and vascular smooth muscle diastolic function. At present,a wide range of research has been conducted in 133-AR in the human body tissues and organs of different physiological pathology processes,though there are still many unsolved problems.

关 键 词：Β3肾上腺素能受体 信号转导 一氧化氮合酶 脂肪组织 心力衰竭 

分 类 号：R59[医药卫生—内科学]