围体外循环期肺保护的研究进展  

Research Progress of Lung Protection during Cardiopulmonary Bypass

作　　者：朱贤[1,2] 姚建民[1] 

机构地区：[1]北京军区总医院心肺一区,北京100700 [2]安徽医科大学,合肥230032

出　　处：《医学综述》2013年第20期3714-3717,共4页Medical Recapitulate

摘　　要：体外循环肺损伤是心脏外科手术后常见的并发症。导致肺损伤的原因包括炎性反应,缺血/再灌注损伤,凝血功能障碍等。目前针对肺损伤的保护措施主要有:肺动脉灌注,白细胞滤器,药物,超滤,机械通气,远端缺血预处理,微型循环技术,内皮祖细胞,体外循环装置的改进等。尽管肺保护相关研究已取得一系列重大进展,但其合理的应用方式及实际临床效果仍然存在争议,有待进一步验证。Lung injury, induced by cardiopulmonary bypass （ CPB ） after cardiac surgery, is a common complication. Factors resulting in lung injury include inflammatory response,ischemia-reperfusion injury and coagulation dysfunction. Currently,strategies to prevent lung injury contain ： lung perfusion, leukocyte deple- tion, medication, ultrafiltration, mechanic ventilation, remote ischemie preconditioning, and minimized extra- corporeal circulation system, endothelial progenitor cells,and improved CPB technology. Although a great pro- gress has been achieved in lung protection, controversies in reasonable application and practical clinical effect still exist and further validation is needed.

关 键 词：肺损伤 肺保护 体外循环 心脏外科 

分 类 号：R654.1[医药卫生—外科学]