糖尿病肾病发病机制的研究进展  

Research Progress in Pathogenesis of Diabetic Nephropathy

作　　者：于晶[1] 赵秀峰[1] 袁晓环[2] 

机构地区：[1]牡丹江医学院红旗医院肾内科,黑龙江牡丹江157100 [2]牡丹江医学院黑龙江省抗纤维化生物治疗重点实验室,黑龙江牡丹江157011

出　　处：《医学综述》2013年第20期3757-3760,共4页Medical Recapitulate

基　　金：黑龙江省卫生厅项目(2011-306)

摘　　要：糖尿病是引起晚期肾病的主要原因,糖尿病肾病是不会在缺少高血糖的情况下发生的,甚至在有遗传倾向时没有高血糖也不会导致糖尿病肾病。基因多态性在糖尿病肾病的发生、发展中也有重要作用。近年来,一些学者提出了其有很多因子介入的发病机制。目前治疗糖尿病的主要方法为控制血糖、降血压、控制血脂并禁止吸烟。控制血糖是治疗的关键点,胰腺移植是降低肾损伤的最好方法。Diabetes is the main reason of end-stage renal disease. Diabetie nephropathy will not happen if there is no hyperglycemia, even when there is a genetic predisposition. Gene polymorphism plays an important role in diabetic nephropathy development. In recent years, some scholars put forward many factors involved in the pathogenesis of the disease. The current treatments of diabetesinelude blood glucose control, blood pressure control,lipid control and prohibition from smoking. Control of blood sugar is the key point of the treatment,and pancreas transplantation is the best WgY to reduce renal injury,

关 键 词：糖尿病肾病 细胞外基质 细胞因子 

分 类 号：R587.2[医药卫生—内分泌]