口服补液盐Ⅲ治疗儿童单纯型抗生素相关性腹泻病疗效观察  

The Efficacy of Oral Rehydration Salts Ⅲ in the Treatment of Simple Antibiotic-Associated Diarrhea

作　　者：黄娟[1] 舒俊华[1] 罗燕军[1] 石祖亮[1] 何学琴[1] 

机构地区：[1]湖北省妇幼保健院,湖北武汉430072

出　　处：《儿科药学杂志》2013年第11期15-18,共4页Journal of Pediatric Pharmacy

基　　金：湖北省自然科学基金项目(2009CDZ021)

摘　　要：目的:观察口服补液盐Ⅲ治疗儿童单纯型抗生素相关性腹泻(ADD)的临床疗效。方法:将72例轻、中度单纯型ADD患儿随机分为实验组和对照组各36例。所有患儿均停用或更换抗生素,对照组予WHO标准口服补液盐I,实验组予低渗口服补液盐Ⅲ,4 h后重新评估,治疗失败者改用静脉输液,成功者继续口服补液,根据患儿脱水程度调整剂量至72 h结束。记录患儿每日大便总量及大便次数,采用Roch P800自动分析仪检测补液后24 h、48 h及72 h血钠及尿钠浓度。结果:实验组和对照组口服补液4 h后额外静脉补液例数分别为1例(2.8%)和7例(19.4%),两组比较差异有统计学意义(P<0.05);两组患儿24 h、48 h及72 h血钠及尿钠均在正常范围,差异无统计学意义(P>0.05);实验组和对照组72 h总有效率分别为94.4%和86.1%,差异无统计学意义(P>0.05),但实验组显效率显著高于对照组(69.4%vs 33.3%),差异有统计学意义(P<0.01);两组患儿腹泻次数、腹泻时间、大便量三项指标均显著低于对照组,差异有统计学意义(P<0.01)。结论:口服补液盐Ⅲ与标准口服补液盐I疗效相当,但前者显效率显著高于后者。口服补液盐Ⅲ能显著减少大便量及大便次数,缩短病程,口感好,患儿依从性好,可减少额外静脉补液需求,值得临床推广应用。Objective： To observe the efficacy of oral rehydration salts III in the treatment of children＇s simple antibiotic-associated diarrhea. Methods： Seventy-two children with mild-to-moderate simple antibiotic-associated diarrhea were randomly divided into a experimental group and a control group equally. All antibiotics were stopped or changed. The control group was treated with oral WHO ,tandard oral rehydration salts I, while the treatment group was treated with oral rehydration salts III. After treatment for four hours, patients switched to intravenous infusion when treatment failure; the rest continued oral rehydration. Daily stool weight and frequency were recorded. The concentration of sodium in blood and urine after 24 hours, 48 hours and 72 hours were detected by B och P 800 automatic analyzer. Results： The number of patients needing additional intravenous rehydration in the experimental group and the control group after four hours were one （2.8%） and seven （19.4%）, respectively; the difference was significant （P〈0.05）. The serum sodium and urine sodium of the two groups after 24 hours, 48 hours and 72 hours were within the normal range; there was no significant difference （P〉0. 05）. The total efficiency of the two groups after 72 hours were 94.4% and 86. 1%, respectively; the difference was not statisticaliy significant （P〉0. 05 ）. However, the visible effective rate of the experimental group was higher than that of the control group （69.4% and 33.3%, respectively） （P〈0.01）. The stool weight, frequency and diarrhea course of the experimental group were significantly lower than those of the control group （P〈0.01）. Conclusions： Oral rehydration salts II! and oral rehydration sats I have equivalent efficacy in simple antibiotic-associated diarrhea. But it can significantly reduce the stool weight, frequency and diarrhea course. Because of good taste, the adherence in children is high. It can reduce the demand for additional intravenous rehydration, and worthy

关 键 词：口服补液盐Ⅲ 口服补液盐I 抗生素相关性腹泻 

分 类 号：R725.7[医药卫生—儿科]