喜炎平注射液治疗小儿细菌性肺炎的随机对照研究及其对血清细胞因子的影响  

Xiyanping Injection in the Treatment of Bacterial Pneumonia in Children and Its Influence on Serum Cytokines: A Randomized Controlled Trial

作　　者：陈陵海 吴悦[1] 王丽霞[1] 刘艳彬[1] 郑权[1] 张思智[2] 

机构地区：[1]四川省成都市温江区人民医院,四川成都611130 [2]四川省人民医院,四川成都610072

出　　处：《儿科药学杂志》2013年第11期31-33,共3页Journal of Pediatric Pharmacy

摘　　要：目的：观察喜炎平治疗小儿细菌性肺炎的疗效及其对血清细胞因子IL-1B、IL-6、IL-8、TNF-a的影响，探讨其免疫作用机制。方法：将94例小儿细菌性肺炎患儿随机分为对照组和治疗组各47例，均给予头孢噻肟50—100mg／（kg·d）加入5％GS100～250mL中静脉滴注，3次／日；治疗组在此基础上加用喜炎平注射液5～10mg／（kg·d）加入5％GS或生理盐水100～150mL中缓慢静脉滴注；两组均以5d为1疗程，治疗2～3疗程之后停3d再治疗3d，并酌情给予止咳、祛痰等对症治疗，观察疗效；检测两组患儿治疗前后血清IL-1β、IL-6、IL-8、TNF-a水平，进行对比分析。结果：与治疗前比较，治疗后两组患儿血清IL-1β、IL-6、IL-8、TNF—a水平均降低（P〈0．05），治疗组比对照组降低更明显（P〈0．05）；治疗组痊愈率、总有效率分别为68．09％、93．62％，对照组分别为48．94％、80．85％，两组比较差异有统计学意义（P〈0．05）。结论：喜炎平注射液治疗小儿细菌性肺炎的机制可能与改变细胞因子水平、调节免疫功能有关。Objective： To observe the efficacy of Xiyanping injection in the treatment of bacterial pneumonia in children and its influence on serum cytokines IL-1β, IL-6, IL-8, and TNF-ct. Methods： Ninety-four eases of children with bacterial pneumonia were randomly divided into a control group and a treatment group equally. Both groups were given cefotaxime 50 - 100 mg/（kg·d） with 5% GS 100 -250 mL 3 times per day by intravenous infusion. On this basis, the treatment group received Xiyanping injection 5 - 10 rag/（ kg·d） intravenously. The treatment course of the two groups was five days. After treatment for two to three courses, the therapy was stopped for three days, and then the patients L were retreated for three days. According to the patients＇ condition, antitussive and expectorant agents were given. The effects were observed. The level of serum IL-1β, IL-6, IL-8 and TNF-α in both groups before and after treatment were detected： Results： The level of serum IL-β, IL-6, IL-8 and TNF-α in the two groups after treatment were significantly lower than those before treattnent （P〈0.05）. The cure rate and the total effective rate in the treatment group were 68.09% and 93.62% ; in the control group were 48.94% and 80. 85% ; the difference was statistically significant （P〈0. 05）. Conclusions： The mechanism of drug action of Xiyanping in treating infantile pneumonia may change eytokines levels and regulate immune functions.

关 键 词：喜炎平 儿童 肺炎 细胞因子 头孢噻肟 

分 类 号：R722.6[医药卫生—儿科]