甜菜碱盐酸盐的合成方法研究  

Synthesis of betaine hydrochloride

作　　者：阿不都拉江.那斯尔 王倩[2] 宋明秀[1] 孙洪志[1] 王付燕[1] 朱维群[1] 

机构地区：[1]山东大学化学与化工学院,山东济南250100 [2]山东大学国家胶体材料工程技术研究中心,山东济南250100

出　　处：《化学试剂》2013年第11期983-986,共4页Chemical Reagents

摘　　要：以氯乙酸和三甲胺为原料,在N,N-二甲基甲酰胺(DMF)溶剂中通过季铵化反应,得到了标题化合物,经IR、1HNMR和元素分析等方法对其结构进行了表征。探讨了溶剂选择、原料配比和反应温度、时间等因素对该反应的影响,其最优反应条件为:以N,N-二甲基甲酰胺为溶剂,n(三甲胺)∶n(氯乙酸)=1.7∶1,反应温度为60℃,时间为5 h,反应收率可达95%以上。该方法较好地解决了现有合成工艺存在的分离纯化难、操作复杂、产品纯度低、生产成本高等问题,提供一种合成甜菜碱盐酸盐节能环保的工艺方法。Betaine hydrochloride was synthesized from trime-thylamine and chloroactic acid by quaternization reaction with DMF as solvent. The structures were confirmed by ^1 HNMR, IR and elemental analysis. The effect of solvent, mole ratio of raw material, reaction temperature and reaction time on the quaterisation reaction was discussed. The yield of the products was more than 95% under the following optimized conditions： n（trimethylamine） ： n （ chloroactic acid） = 1.7 ： 1, reaction temperature was 60 ℃, reaction time was 5 h with DMF as solvent. The synthetic method can solve the problems of the current process such as complex separation and purification, low purity and high cost. It may be a synthesis method of en-ergy-saving and environmental protection.

关 键 词：甜菜碱盐酸盐 合成 溶剂 分离 收率 

分 类 号：O622.6[理学—有机化学]