HSP患儿生化指标与肾脏损害的相关性分析  

Correlation analysis of biochemical indexes of patients with HSP and renal damage

作　　者：刘伟华[1] 白蕊萍 张北宁[1] 杨宾 肖延风[3] 

机构地区：[1]西安市第一医院,陕西西安710002 [2]西安市长安区妇幼保健院,陕西西安710100 [3]西安交通大学第二附属医院,陕西西安710004

出　　处：《中国妇幼健康研究》2013年第5期674-676,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨参与过敏性紫癜(HSP)患儿肾脏损害的可能危险因素,为预防过敏性紫癜肾脏损害提供理论依据。方法 60例过敏性紫癜患儿入院后检查尿常规、血尿素氮(BUN)、肌酐(Scr)、C反应蛋白(CRP)、血沉(ESR)、谷草转氧酶(AST)、磷酸肌酸同工酶(CK-MB)、血胱抑素C(CysC)、尿Ⅳ型胶原纤维蛋白(尿Ⅳ-C)、尿N-乙酰-β-D-氨基葡萄糖苷酶(尿NAG酶)等多项生化指标,将所有资料进行线性相关及多元线性回归分析。结果 60例过敏性紫癜患儿肾脏损害的检出率为35%,线性相关分析显示:总蛋白(TP)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、谷丙转氨酶(ALT)、Scr与BUN呈正相关(r值分别为0.23,0.16,0.18,0.22,0.12,0.14,均P<0.05),且白蛋白(ALB)、球蛋白(GLB)、CRP、ESR、AST、CKMB亦与BUN呈正相关(r值分别为0.38,0.32,0.56,0.49,0.46,0.35,均P<0.01);进一步多元线性回归显示CRP、AST、CK-MB及ESR与BUN密切相关,其中决定系数R=0.901,R^2=0.812。结论 CRP、AST、CK-MR及ESR可能与HSP患儿肾脏损害的程度相关联,在HSP的治疗中对以上指标应该引起足够重视。Objective To investigate the possible risk factors involving the renal damage of children with henoch -schonlein purpura （ HSP） and to provide theoretical basis for the prevention of renal damage .Methods Several biochemical indexes of 60 HSP cases , including routine urinalysis, BUN, Scr, CRP, ESR, AST, CK-MB, CysC, urinary IV-C and urinary NAG, were detected after hospitalization . Linear correlation analysis and multiple linear regression analysis were conducted on all of the data .Results The detection rate of renal damage among 60 cases of HSP was 35%.Linear correlation analysis showed that BUN was positively related with TP , TBIL, DBIL, IBIL, ALT and Scr （r value was 0.23, 0.16, 0.18, 0.22, 0.12 and 0.14, respectively, all P〈0.05）, and that RUN was positively related with ALB, GLB, CRP, ESR, AST and CK-MB （r value was 0.38, 0.32, 0.56, 0.49, 0.46 and 0.35, respectively, all P〈0.01）. Further multivariate linear regression analysis showed that CRP , AST, CK-MB and ESR were closely related with BUN , and the coefficient of determination R was 0.901 and R^2 was 0.812.Conclusion CRP, AST, CK-MB and ESR may be related with the severity of renal damage of HSP children .In the treatment of HSP enough attention should be paid to the above factors .

关 键 词：过敏性紫癜 肾脏损害 血尿素氮 C反应蛋白 多元线性回归分析 

分 类 号：R725[医药卫生—儿科]