血清IFN-γ、IL-10及sFlt-1与重度子痫前期发病的相关性探讨  

Correlation between pathogenesis of severe preeclampsia and serum level of IFN-γ,IL-10 and sFlt-1

作　　者：张飞跃[1,2] 主改侠[1] 陈茜[1] 

机构地区：[1]西安交通大学医学院第二附属医院妇产科,陕西西安710004 [2]山东省淄博市中心医院妇产科,山东淄博255036

出　　处：《中国妇幼健康研究》2013年第5期726-728,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的：探讨早发型重度子痫前期和晚发型重度子痫前期发病机制的差异。方法取初诊初治的早发型、晚发型重度子痫前期患者和同期正常妊娠者分娩前清晨空腹静脉血4～5mL，用ELISA法测定各组样本血清中干扰素（ IFN）-γ、白介素（IL）-10、IFN-γ/IL-10比值及可溶性血管内皮生长因子受体l（sFlt-1）的含量，并对结果进行分析。结果重度子痫前期患者血清中IFN-γ、IFN-γ/IL-10比值及sFlt-1含量均高于对照组，IL-10的含量低于对照组。早发型重度子痫前期血清中IFN-γ/IL-10比值变化与sFlt-1的变化具有相关性（ r＝0．941，P＜0．001）；而晚发型重度子痫前期患者的这种相关性无统计学意义。结论患者血清中IFN-γ、sFlt-1以及IFN-γ/IL-10比值升高致胎盘缺血缺氧是重度子痫前期致病因素之一，早发型与晚发型重度子痫前期在发病机制上存在差异。Objective To study the difference in the pathogenesis of early-onset severe preeclampsia （EOSP） and late-onset severe preeclampsia （LOSP）.Methods Vein fasting blood 4-5mL were collected from newly diagnosed untreated patients with EOSP , LOSP and the normal control patients before delivery .Enzyme linked immunosorbent assay （ELISA） was used to detect interferon-γ（IFN-γ）level, interleukin-10 （IL-10） level, ratio of IFN-γ/IL-10 and soluble fms-like tyrosine kinase-1（sFlt-1） in the serum.Results Compared with the control group , serum level of IFN-γ, IFN-γ/IL-10 ratio and sFlt-1 level were higher but IL-10 level was lower in patients with severe preeclampsia.There was a positive correlation between IFN-γ/IL-10 ratio and sFlt-1 level in patients with EOSP （r=0.941,P〈0.001）, but the correlation in patients with LOSP was not significant .Conclusion The excess of serum IFN-γ, sFlt-1 and elevated IFN-γ/IL-10 ratio lead to severe preeclampsia .The pathogenesis of EOSP and LOSP is different .

关 键 词：重度子痫前期 母胎耐受 移植免疫耐受 可溶性血管内皮生长因子受体-1 免疫平衡 

分 类 号：R714[医药卫生—妇产科学]