几丁糖联合补佳乐在宫腔粘连术后的预防疗效分析  

The effectiveness analysis of infusing medical chitosan and estradiol valerate in preventing adhesion recurrence after transcervical recection

作　　者：谢元媚[1] 张秋实[1] 刘雯雯[1] 

机构地区：[1]广东省第二人民医院妇科,广东广州510317

出　　处：《中国妇幼健康研究》2013年第5期740-742,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的观察几丁糖与补佳乐联合应用在中~重度宫腔粘连术后预防再粘连的效果。方法将68例行宫腔镜下粘连分离术的中、重度宫腔粘连患者做为研究对象,按术后使用防粘连方法的不同随机分成两组。研究组34例,术毕宫腔内放置2%几丁糖3mL及术后口服补佳乐;对照组34例,术毕宫腔放置节育器及口服补佳乐;补佳乐口服方法为2mg/次,2次/日,共21天,疗程为3个月。观察两组术后宫腔形态恢复情况以评定疗效。结果对68例宫内节育器患者术后随访6个月,研究组24例月经恢复正常,对照组20例恢复正常;研究组4例月经量较术前增多,对照组6例;研究组1例仍闭经,对照组3例闭经;两组患者10例术后周期性腹痛症状均消失。研究组总有效率94.11%,对照组总有效率73.53%,两组比较差异有统计学意义(x^2=5.314,P<0.05)。结论几丁糖联合补佳乐适合宫腔镜下分离宫腔粘连术后预防宫腔再次粘连。Objective To study the effect of medical chitosan and estradiol valerate in preventing adhesion recurrence after transcervical resection of moderate or severe intrauterine adhesions （IUA）.Methods Clinical data of 68 patients with moderate or severe IUA who underwent transcervical resection were studied retrospectively .They were divided into two groups according to different therapy methods . Study group （34 patients ） received 2% medical chitosan 3ml in intrauterine cavity and oral administration of estradiol valerate after transcervial resection , while patients in control group were placed with intrauterine device （ IUD） and oral administratin of estradiol valerate after operation with same usage .Estradiol valerate was taken 2mg per time, twice per day for 21 days.The course was 3 months.The restore of intrauterine cavity were studied .Results There were 68 cases of IUD followed up for 6 months after operation .In the study group 24 cases recovered with normal menstruation , while in the control group 20 recovered .There were 4 in the study group and 6 in the control group with much more menstrual blood volume than before .Amenorrhea occurred in 1 case in the study group and 3 cases in the control group.The overall effective rate of the study group and the control group was 94.11% and 73.53%, respectively, and there was significant difference between two groups （χ^2 =5.314,P 〈0.05）.Conclusion Infusing medical chitosan and estradiol valerate after transcervical resection is an effective method in preventing adhesion recurrence .

关 键 词：几丁糖 补佳乐 宫内节育器 宫腔粘连 

分 类 号：R713[医药卫生—妇产科学]