雌性小鼠受小剂量γ射线照射导致非整倍体胚胎和显性致死的研究  

FREQUENCIES OF ANEUPLOID AND DOMINANT LETHAL MUTATIONS IN YOUNG FEMALE MICE INDUCED BY LOW DOSES γ-RAYS

作　　者：姚素艳[1] 张朝阳[1] 戴连连 高长文 

机构地区：[1]卫生部工业卫生实验所

出　　处：《辐射研究与辐射工艺学报》1991年第4期214-218,共5页Journal of Radiation Research and Radiation Processing

基　　金：国家核安全技术研究;"七五"科技攻关课题"核电站电离辐射对人群影响的卫生学评价"的分题

摘　　要：本文报道低龄雌鼠受到0.15—1.56Gy,0.05Gy/min^(60)Coγ射线照射后,过一定时间与正常雄鼠同笼。在胚胎满9.5—11d时活杀孕鼠,观察其染色体异常胚胎发生率及显性致死突变率与剂量的关系。结果表明,在剂量为0.15Gy时,其非整倍体胚胎发生率未见增加;在0.50Gy以上时,似随剂量增加而增加。但三体胚胎的剂量效应关系不明显。观察到的显性致死突变率与受照剂量呈直线相关。在上述剂量范围内,显性致死突变率为5.59％。显性致死突变的效应比非整倍体胚胎的效应高。Relationship between aneuploid, dominant lethal mutaions and dosesin young female mice induced by low doses γ-rays was examinated. The results sug-gest that the frequencies of aneuploid of embryos were not found increase at 0.15 Gy,but increases at over 0.50 Gy after irradiation in groups. The frequencies of ancup-loid and dominant lethal mutations were increased with increasing doses and fittedlinear relationship.The dose-response relationship of trisomic was not significant. Thefrequency of dominant lethal mutations induced by ^(60)Co γ irradiation is 5.59%. Theeffect of dominant lethal mutation is higher than that of the aneuploid.

关 键 词：胚胎 非整倍体 显性致死突变 辐射 

分 类 号：Q345.1[生物学—遗传学]