NB-UVB治疗对白癜风患者外周血IL-17表达的影响  

Influences of IL-17 cytokine in peripheral blood of patients with vitiligo with NB-UVB therapy

作　　者：郭洪飞[1] 马学良[1] 张厚毅[2] 王宝林[3] 

机构地区：[1]济宁医学院附属滕州市中心人民医院皮肤科,山东滕州277500 [2]济宁医学院附属滕州市中心人民医院检验科,山东滕州277500 [3]枣庄市立医院皮肤科,山东枣庄277000

出　　处：《世界最新医学信息文摘》2013年第16期32-33,共2页World Latest Medicine Information Electronic Version

摘　　要：目的探讨NB-UVB对白癜风患者外周血IL-17表达的影响及其可能的免疫学机制。方法38例白癜风患者作为实验组，采用NB-UVB进行治疗，20例健康体检者作为对照组，采用酶联免疫吸附法测定NB-UVB治疗前后白癜风患者及健康体检者外周血IL-17的表达水平。结果白癜风患者外周血IL-17表达水平明显高于对照组，差异有统计学意义（P〈0．05）；NB-UVB治疗后白癜风患者外周血IL-17表达水平较治疗前降低，差异有统计学意义（P〈0．05）；NB-UVB治疗后白癜风患者外周血IL-17表达水平稍高于对照组，但差异无统计学意义（P〉0．05）。结论NB-UVB可能通过影响白癜风患者外周血中IL-17的表达来发挥治疗作用。Objective To study the level of IL-17 in peripheral blood of patients with vitiligo, and to observe the possible mechanism of NB-UVB therapy. Methods The level cytokine in peripheral blood of patients with vitiligo, and to explore the possible immune mechanism of NB-UVB therapy of IL-17 in peripheral blood from 38 vitiligo patients and 20 normal control groups were measured by enzyme linked immunosorbent assay. Results The level of IL-17 in vitiligo patients was higher than the control group （P 〈0.05）; The level of IL-17 in vitiligo patients after NB-UVB therapy was lower, and the difference were significant before treatment （P 〈0.05）; The level of IL-17 in vitiligo patients after NB-UVB therapy was higher than the control group （P 〉0.05）, but the differences were not significant. Conclusion NB-UVB may influence the level of IL-17 cytokine in peripheral blood of patients with vitiligo to plays a therapeutic role.

关 键 词：白癜风 NB-UVB IL-17 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]