腹膜淋巴孔研究的新进展  

Advances in the Research of the Peritoneal Lymphatic Stomata in Human

作　　者：李慧[1] 李继承[1] 

机构地区：[1]浙江大学细胞生物学与组织工程学研究所淋巴学研究室,杭州310031

出　　处：《中国医学科学院学报》2000年第6期585-588,共4页Acta Academiae Medicinae Sinicae

摘　　要：腹膜淋巴孔是腹膜下毛细淋巴管在腹膜间皮细胞间的开口。通过淋巴孔，腹膜腔与淋巴管系直接相通，它具有主动吸收功能，是腹膜腔内物质转归的最主要部位。淋巴孔与肝硬化腹水的转归、连续不卧床腹膜透析的失超滤、肿瘤细胞的转移和扩散等密切相关。淋巴孔还具有调控和免疫功能。 NO对淋巴孔调控作用是目前研究的热点，它通过激活鸟苷酸环化酶途径，增加细胞内 cGMP，降低 Ca2＋水平，使淋巴孔产生强烈的舒张，淋巴孔开放数目增多、孔径增大，淋巴引流作用增强。而中药通过提高内源性 NO水平，也能对腹膜淋巴孔进行调控，以促腹水转归。Peritoneal lymphatic stomata are small openings of the subperitoneal lymphatic vessels on the free surface of the mesothelium.The peritoneal cavity is connected with lymphatic system via these small openings which are considered to be the main passageway that can absorb matter from the peritoneal cavity.The lymphatic stomata are claimed to be involved in many clinic procedures,such as ascits elimination;ultrafiltration failure on the continuous ambulatory peritoneal dialysis;metastasis of tumor cells from the peritoneal cavity,and so on.It was reported that the cellular factor- NO(i.e.endothelium- derived relaxing factor, EDRF)can enhance the patency of the stomata and lymphatic absorption of the stomata by stimulating guanylate way,then increasing the concentration of the cGMP,decreasing the concentration of the [Ca2＋ ]and as a result diastoling the lymphatic stomata. Some traditional Chinese medicines,which can enhance absorption of ascitis,have a regulative function on the stomata by enhancing the NO concentration.

关 键 词：淋巴孔 腹膜 间皮细胞 淋巴引流 调控 

分 类 号：R331.4[医药卫生—人体生理学]