止咳平喘膜剂的研制与穴位作用机理初步探讨  

Studies on the Antitussive and Antiasthmatic Film

作　　者：刘建平[1] 李运曼 张灵霞[1] 孙宇[1] 

机构地区：[1]中国药科大学药剂学教研室 [2]生理学教研室,南京210009

出　　处：《中国药科大学学报》2000年第6期426-429,共4页Journal of China Pharmaceutical University

基　　金：江苏省科委社会发展基金资助项目!(No.BS97076)

摘　　要：研制了中药穴位经皮给药系统——止咳平喘膜剂。采用双室渗 透扩散装置考察膜剂的经皮吸收性能; 测定膜剂于小鼠膻中、肺腧等穴位用药后的穴位电阻 值、Na+-K+-ATP酶活性和经皮吸收量。结果表明，膜剂中有效成分之一的黄芩甙以零 级速率透过皮肤,渗透性能良好;穴位给药后皮肤电阻值降低，酶活性升高，经皮吸收量增加 ,与非穴位给药相比有显著性差异。A antitussive and antiasthmatic film was developed and its acupuncture mechanism was studied. The electrical resistance of acupuncture points wa s decreased, Na+ -K+-ATP enzyme activity and permeation drug amount of acu puncture points were increased while the film was pasted on the shanzhong and feishu acupuncture points.

关 键 词：经皮给药系统 止咳平喘膜剂 穴位 电阻 机理 

分 类 号：R944[医药卫生—药剂学]