重要荧光纳米材料的合成策略及其在生物医学上的应用研究进展  

Review of Synthesis and Biomedical Applications of Typical Fluorescent Nanomaterials

作　　者：杨霄[1,2] 季天骄[2] 刘希曦[1,2] 魏景艳[1] 聂广军[2] 

机构地区：[1]国家纳米科学中心,纳米生物效应和安全性重点实验室,北京100190 [2]吉林大学药学院,长春130021

出　　处：《生物物理学报》2013年第8期545-566,共22页Acta Biophysica Sinica

基　　金："973"计划项目(2012CB934004)~~

摘　　要：荧光纳米材料具备多种优良的理化性质,如荧光发射谱带窄、尺寸形貌易调控、表面易于进行修饰以实现多功能化等。因此,荧光纳米材料在很多领域都开始崭露头角,尤其在生物医学领域受到越来越多的关注,如应用于生物进程中机理的阐释及疾病病程的预防诊断等。结合生物微环境特点进行荧光纳米材料的设计及合成,可最大限度地发挥其独特的光学优势,并能使其在重要的生物医学研究中克服传统荧光探针的不足,提高荧光材料的稳定性及精确性。Fluorescent nanomaterials with favorable physicochemical properties, such as narrow fluorescent emission, size-dependent controllable optical properties and capability of multifunctionalization have been actively investigated in a wide spectrum of biological applications. Combined with specific biological microenvironment properties, design and synthesis of novel fluorescent nanomaterials to fully exploit the unique optical properties of these fluorescent nanomaterials would endow them considerable advantages over traditional fluorescent molecules and ensure potentially important applications, such as in diagnosis of diseased conditions and in deciphering biological mechanism and processes. Although certain technical barriers need to be overcome, further development of these fluorescent nanomaterials for specific biomedical applications will guarantee rapid commercialization of these promising new class fluorescent probes.

关 键 词：荧光染料分子 量子点 贵金属团簇 生物成像 

分 类 号：O657.3[理学—分析化学]