哮喘患儿和非哮喘儿童血中抗肺炎链球菌荚膜多糖IgG水平的差异  

The difference of anti-pneumococcal capsular polysaccharide IgG levels in plasma of asthmatic and non-asthmatic children

作　　者：陈蒙[1] 田曼[1] 陆悦倩[1] 赵德育[1] 

机构地区：[1]南京医科大学附属南京儿童医院呼吸科,江苏南京210008

出　　处：《临床儿科杂志》2013年第11期1046-1049,共4页Journal of Clinical Pediatrics

基　　金：江苏省卫生厅指导性科研项目(No.Z201213)

摘　　要：目的探讨哮喘患儿对侵袭性肺炎链球菌疾病(IPD)易感性的体液免疫机制。方法收集43例哮喘患儿和20例非哮喘择期手术患儿的血浆标本,用酶联免疫吸附法(ELISA)测定并比较两组血中抗肺炎链球菌荚膜多糖(PPS)IgG水平。结果哮喘患儿血中抗PPS-14、19A及23F 3种血清型IgG水平均高于非哮喘儿童,差异有统计学意义(P均<0.05);其3型IgG水平达到保护性抗体水平(≥0.2μg/ml)以上的比例均为100%。结论哮喘患儿体内防御IPD的抗PPS-IgG免疫功能正常,但哮喘患儿可能比非哮喘儿童更容易发生肺炎链球菌感染或定植。Objectives To explore the humoral immunologic mechanisms of the susceptibility to invasive pneumococcal diseases （IPD） in asthmatic children. Methods Plasma samples were collected from 43 asthmatic and 20 non-asthmatic chil-dren. Anit-pneumococcal capsular polysaccharide （PPS）-IgG concentrations were measured by enzyme-linked immunosorbent assays. Results The mean concentrations of anti-PPS 14, 19A and 23F-IgG were signiifcantly higher in asthmatic children than in non-asthmatic children （P〈0.05）. The ratios of the asthmatic children who had anti-PPS 14, 19A and 23F-IgG concentrations higher than the protective antibody level （≥0.2 μg/ml ） were 100%for all the serotypes. Conclusions The immune responses of producing anti-PPS IgG to defense IPD were normal in asthmatic children. Asthmatic children may be more susceptive to pneumococcal infection or colonization than non-asthmatic children.

关 键 词：哮喘 侵袭性肺炎链球菌疾病 抗肺炎链球菌荚膜多糖IgG 

分 类 号：R725.6[医药卫生—儿科]