痘病毒宿主范围因子及其作用机制研究进展  

Progress on Host Range Factors and Their Mechanisms of Poxvirus

作　　者：白刚[1] 贾怀杰[1] 何小兵[1] 景志忠[1] 

机构地区：[1]中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,农业部兽医公共卫生重点实验室,兰州730046

出　　处：《病毒学报》2013年第6期655-661,共7页Chinese Journal of Virology

基　　金：国家十二五"863"课题(2011AA10A211);甘肃省农业生物技术研究专项(GNSW-2012-16);家畜疫病病原生物国家重点实验室自主研究课题

摘　　要：痘病毒是已知病毒中基因组最大、宿主谱最广和危害最严重的人兽共患病病原之一。随着病原和宿主互作的分子生物学、功能基因组学以及免疫学相关技术的发展,痘病毒宿主范围因子及其相关作用机制被相继发现和研究,这为痘病毒的组织嗜性和宿主特异性的阐明奠定了分子基础。本文将通过对脊椎动物重要痘病毒属主要成员的宿主范围因子及其作用机制的介绍,以加深对痘病毒的分子遗传演化、组织嗜性和跨宿主种间感染机制的理解和认识。Poxvirus is one of the most serious zoonosis path host spectrum. With the development of molecular biology ogens, which has largest genome and broadest functional genomics, and immunology-related technology, the interactions between pathogen and the host, particularly a large array of host range factors and their functions have been increasingly discovered. These findings provide references for the molecular basis of poxvirus tissue tropism and host specificity. This review focus on the introduction of host range factors in major members of Chordopoxvirinae to highlight the understanding of the mechanisms of molecu- lar genetic evolution, the host tropism, and cross-species infection of poxviruses.

关 键 词：痘病毒 宿主范围因子 组织嗜性 跨种感染 免疫应答 

分 类 号：R373.9[医药卫生—病原生物学]