右美托咪定对老年手术患者术后认知功能障碍的影响  

Effect of dexmedetominine on postoperative cognitive dysfunction of elder patients underwent general anesthesia

作　　者：郑颖梅[1] 张葆[1] 李立[1] 

机构地区：[1]常州市第二人民医院麻醉科,江苏省213003

出　　处：《江苏医药》2013年第22期2726-2728,共3页Jiangsu Medical Journal

摘　　要：目的探讨右美托咪定对老年手术患者术后认知功能障碍(POCD)的影响。方法全身麻醉下胸科老年手术患者60例随机均分为两组:D组在诱导前10min静脉泵入右美托咪定1μg/kg,后以0.2μg·kg-1·h-1泵注至手术结束前30min;C组静脉泵注等量生理盐水对照。记录两组术前1d、术后6、24h、3、5、7d简易智力状态检查量表(MMSE)评分和术后相应时点POCD发生率。结果术后6h和24h,D组的MMSE评分高于C组[(26.6±1.5)分vs.(25.1±1.7)分和(27.2±1.6)分vs.(25.7±2.0)分](P<0.05),POCD发生率低于C组(23.3%vs.46.7%和16.7%vs.40.0%)(P<0.05)。结论右美托咪定可降低老年手术患者早期POCD的发生。Objective To investigate the effect of dexmedetominine on postoperative ~ognitive dysfunction（POCD） of elder patients underwent general anesthesia. Methods Sixty elder patients scheduled for thoracic surgery under general anesthesia were equally randomized into two groups. The patients in group D were infused dexmedetominine 1μg/kg in 10 rain before induction, which was followed by infusion of 0. 2μ· kg^-1 · h^-1 untill 30 rain before the end of operatiorL Group C was given normal saline as the control. The scores of mini-mentalstate examination（MMSE） and the incidence rate of POCD were recorded 1 d before surgery, at 6,24 h, and on the 3rd , 5th and 7th d after operation. Results At 6 and 24 hours after operation,the scores of MMSE were higher[（26.6±1.5） points vs. （25.1±1.7） points and （27.2±1.6） points vs. （25.7±2.0） points] and the incidence rates of POCD were lower（23.3% vs. 46.7% and 16.7% vs. 40.0%） in group D than those in group C（P〈0.05）. Conclusion Dexmedetominine may decrease the incidence of POCD in the elderly underwent thoracic surgery under general anesthesia.

关 键 词：右美托咪定 认知功能障碍 老年 

分 类 号：R614[医药卫生—麻醉学]