解郁舒心片抗抑郁活性的主要药效学及作用机制  

Pharmacodynamics and mechanism of antidepressant activity of Jieyu Shuxin Tablets

作　　者：谢家骏[1] 罗质璞[2] 黄世杰[2] 乔正东[3] 王建新[4] 

机构地区：[1]上海中医药大学,上海201203 [2]军事医学科学院毒物药物研究所,北京100850 [3]上海市中药研究所,上海201401 [4]复旦大学药学院,上海201203

出　　处：《中成药》2013年第11期2319-2324,共6页Chinese Traditional Patent Medicine

基　　金：国家"重大新药创制"科技重大专项课题(2011ZX09301-009);上海市科委中药现代化专项计划项目(014319303)

摘　　要：目的研究解郁舒心片（贯叶连翘提取物）抗抑郁作用的主要药效学及其作用机制。方法观察解郁舒心片对小鼠悬尾不动时间、大鼠强迫游泳不动时间、小鼠甩头行为频率、与阿朴吗啡协同降温程度、小鼠自主活动次数等指标的影响。结果在125～500mg／kg剂量范围内，灌服解郁舒心片可减少小鼠悬尾不动时间、大鼠强迫游泳不动时间，以及增强小鼠5-羟色胺酸甩头行为效应；可明显加强阿朴吗啡的降温作用，而腹腔注射多巴胺D2受体拮抗剂氟哌啶醇0．3mg／kg能部分拮抗其协同降温作用。灌服解郁舒心片500mg／kg，未发现对小鼠神经系统有明显影响。结论解郁舒心片口服给药具有明显的抗抑郁活性。AIM To investigate pharmacodynamics and antidepressant mechanism of Jieyu Shuxin Tablets （Hypericum perforatum extract）. METHODS The experiment was performed on mice＇ s tail suspension, 5- hydroxytryptophan-head-twitches, apomorphine-induced hypothermia test and the number of automonic activities, and rat＇ s forcing swimming test. RESULTS In the range of 125-500 mg/kg, Jieyu Shuxin Tablets could decrease the immobility time of mice＇ s tail suspension, enhance 5-hydroxytryptophan-induced head-twitches and apomor- phine-induced hypothermia test, and strengthen rat＇ s forcing swimming. But the injection of 0.3 mg/kg haloperidol could antagonize apomorphine-induced temperature decrease in part. The result did not find the influence on nerv- ous system. CONCLUSION Jieyu Shuxin Tablets have obvious antidepressant activity.

关 键 词：解郁舒心片 贯叶连翘提取物 抗抑郁 药效学 悬尾试验 强迫游泳试验 5-羟色胺酸甩头试验 阿朴吗啡降温试验 

分 类 号：R285.5[医药卫生—中药学]