瓜蒌薤白白酒汤对大鼠心肌缺血再灌注损伤的保护作用  

Effect of Gualou Xiebai Baijiu Decoction on myocardial protection in myocardial ischemia reperfusion rats

作　　者：卞海[1] 王雅娟[1] 黄顺[2] 李亚军[3] 孙洪胜[1] 陈赛赛[3] 龙子江[1] 

机构地区：[1]安徽中医药大学药理教研室,安徽合肥230038 [2]安徽中医药大学中西医结合临床学院,安徽合肥230038 [3]安徽省中医院,安徽合肥230038

出　　处：《中成药》2013年第11期2347-2352,共6页Chinese Traditional Patent Medicine

基　　金：高校省级优秀青年人才基金项目(2011SQRL090);2013年度安徽省高等学校省级自然科学研究项目(KJ2013A173)

摘　　要：目的观察瓜蒌薤白和白酒汤对大鼠实验性心肌缺血再灌损伤的保护作用。方法末次给药后30 min,采用冠状动脉左前降支近端结扎的方法建立大鼠心肌缺血模型。结扎30 min后再灌180 min,进行各项指标检测。结果瓜蒌薤白白酒汤能明显降低心肌缺血再灌注后大鼠心电图ST段的抬高,显著改善心肌缺血再灌注后大鼠心肌组织病变,可降低心其全血黏度并明显抑制心肌酶LDH、CK的释放,与模型对照组比较具有统计学差异(P<0.05或P<0.01)。结论瓜蒌薤白白酒汤对大鼠实验性心肌缺血再灌损伤具有保护作用。AIM To observe the protective effect of Gualou Xiebai Baijiu Decoction （Trichosanthis Fructus, Allii macrostemi Bulbus, wine） on myocardial ischemia reperfusion injury in rats. METHODS By tigatig left an-terior descending branch of coronary artery, the model of myocardial ischemia-reperfusion injury in rats was estab- lished and reperfused for 180 rain after ischemia for 30 min, then rats were executed to be measured. RESULTS Compared with the model group, Gualou Xiebai Baijiu Decoction could inhibit ECG S-T segment＇s elevation in rats with myocardial ischemia and reduce the myocardial infarct size. Gualou Xiebai Baijiu Decoction could significantly reduce the release of LDH and Creatine Kinase in serum. Conclusion Gualou Xiebai Baijiu Decoction can protect the myocardial ischemia/reperfusion injury in rats.

关 键 词：瓜蒌薤白白酒汤 心肌缺血再灌注 心电图 血液流变 肌酸激酶 

分 类 号：R285.5[医药卫生—中药学]