通络止痛合剂治疗急性痛风性关节炎临床研究  

Clinical Study in Treatment of Acute Gouty Arthritis with Tongluo Zhitong Mixture

作　　者：李东书[1] 姚岚[1] 孟庆一[1] 

机构地区：[1]沈阳市中医院风湿科,辽宁沈阳110004

出　　处：《辽宁中医杂志》2013年第11期2259-2261,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：沈阳市科技局自然科学基金项目(F11-262-9-53)

摘　　要：目的:观察通络止痛合剂治疗急性痛风性关节炎的疗效并探讨其作用机理。方法:将72例急性痛风性关节炎患者随机分为两组:治疗组37例,用通络止痛合剂治疗;对照组35例,用痛风定胶囊治疗。观察两组病例治疗前后全身症状、体征的改善情况,并分别测定两组患者Glu、TC、TG、ESR、肝功能(ALT、AST)、肾功能(BUN、UA、Cr)等方面的变化情况。结果:通络止痛合剂对急性痛风性关节炎具有良好治疗效果,临床控制率为43.2%,总有效率为91.9%,与痛风定胶囊组比较有明显差异(P<0.05)。通络止痛合剂具有显著的降低血尿酸的作用,与痛风定胶囊无明显差异(P>0.05)。结论:通络止痛合剂具有良好的治疗效果,能显著降低血尿酸,且无明显毒副作用,患者依从性好,是治疗风湿热痹兼血瘀型痛风的有效方药。Objective ： To observe the effect of Tongluo Zhitong mixture in the treatment of acute gouty arthritis and to explore its mechanism of action. Methods ：72 cases of acute gouty arthritis were randomly divided into two groups ：the treatment group of 37 cases with Tongluo Zhitong mixture treatment; 35 cases in the control group with Tongfengding capsule. The two groups were observed before and after treatment with systemic symptoms and signs of improvement, and two groups of patients were measured Glu, TC, TG, ESR, liver function （ ALT, AST） , renal function （ BUN, UA, Cr） changes etc. Results ： Tongluo Zhitong mixture had good therapeutic effect on acute gouty arthritis,and the clinical control rate was 43.2% ,and the total effective rate was 91.9%. Compared with Tongfengding capsule,there was significant difference（ P 〈 0.05 ）. In addition, Tongluo Zhitong mixture had significant functions on reducing uric acid, and compared with Tongfengding capsule, there was no significant difference （ P 〉 0. 05 ）. Conclusion ： Tongluo Zhitong mixture has good treatment effect, and can significantly reduce blood uric acid without obvious toxic side effects. The patient compliance is good. It is an effective prescription to treat rheumatism heat stagnation and blood stasis.

关 键 词：急性痛风性关节炎 临床研究 通络止痛合剂 

分 类 号：R684.3[医药卫生—骨科学]