中西药联合治疗多囊卵巢综合征所致不孕临床观察  

Infertility Treatment in Polycystic Ovary Syndrome with Traditional Chinese Medicine Combined with Western Medicines

作　　者：朱怡[1] 王香桂[2] 

机构地区：[1]杭州市红十字会医院妇产科,杭州310003 [2]浙江省中医院妇科

出　　处：《浙江中西医结合杂志》2013年第11期872-875,885,共5页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察中西药联合治疗多囊卵巢综合征所致不孕的临床疗效。方法:多囊卵巢综合征所致不孕患者40例,随机分为西药组和中西药组各20例;两组均先予达因-35治疗3个月后西药组予氯米芬诱发排卵治疗,中西药组予氯米芬联合中药诱发排卵治疗。结果:40例患者予达因-35治疗3个月后性激素水平较治疗前均有明显改善;诱发排卵治疗后,中西药组妊娠率60%,明显高于西药组的25%(P<0.05),卵泡发育、子宫内膜厚度、基础体温改善优于西药组,两组比较,差异有统计学意义(P<0.05);两组治疗后未妊娠者月经周期均有不同程度的缩短。结论:达因-35能有效调节性激素水平,为诱发排卵治疗创造有利条件;中药可能通过调节下丘脑-垂体-卵巢性腺轴功能和改善子宫内膜容受性,克服氯米芬"抗雌激素样作用",促进卵泡发育和黄体功能,从而提高妊娠率,具有较好的临床疗效。Objective：To observe the clinical effect of using Chinese medicine combined with western medicine in the treatment of infertility in patients with polycystic ovary syndrome. Methods： Forty patients that met the diagnos- tic criteria of this research were randomly divided into western medicine group（A） and Chinese medicine combined with western medicine group （B）. Both groups were given diane-35 for 3 months,and then group A was adminis- tered with clomiphene citrate （CC） alone,while group B was given CC combined with traditional Chinese medicine to induce ovulation. Results：All patients showed significant improvement in sex hormone levels after 3 months of treatment with Diane-35 compared with pre-treatment. Ovulation induction treatment showed that the pregnancy rate of group B（60%） was significantly higher than that of group A（25%）（P〈O.05）. Group B had better improvement in follicular development,endometrial thickness,and basal body temperature （P〈0.05）compared with group A. After treatment,non-pregnant patients＇ menstrual cycle had different degrees of shortening. Conclusion：Diane-35 can ef- fectively regulate the sex hormone levels to create favorable conditions for ovulation induction treatment. Chinese medicine may regulate the function of the hypothalamus-pituitary-ovarian axis,improve endometrial receptivity to overcome the Janti-estrogen-like＇ effects of CC,and promote follicular development and luteal function,thus improve the pregnancy rate and achieve better clinical efficacy in infertility treatment.

关 键 词：多囊卵巢综合征 不孕症 达因-35 氯米芬 中西医结合疗法 

分 类 号：R711.6[医药卫生—妇产科学]