儿童呼吸道合胞病毒感染T细胞亚群变化  

Changes of T Cell Subsets in Children with Respiratory Syncytial Virus Infection

作　　者：夏清[1] 胥亚福 李毅[1] 胥文玉[1] 谢晓平[2] 

机构地区：[1]四川省阿坝州人民医院儿科,四川阿坝州624000 [2]都江堰市人民医院儿科

出　　处：《实用预防医学》2013年第11期1383-1384,共2页Practical Preventive Medicine

基　　金：2012年四川省卫生厅课题(课题编号120411)

摘　　要：目的分析儿童呼吸道合胞病毒感染后T细胞亚群变化情况。方法选择儿童呼吸道合胞病毒感染患者34例为观察组,并选取同期健康体检小儿35例为对照组,在明确诊断后检测两组患者外周血淋巴细胞亚群及T淋巴细胞亚群。结果观察组Th1和Th2比率均高于对照组(P<0.05),Th1/Th2则低于对照组(P<0.05),观察组外周血T淋巴细胞亚群中CD3+和CD8+低于对照组(P<0.05),CD4+高于对照组(P<0.05),且CD4+/CD8+高于对照组(P<0.05)。结论小儿呼吸道合胞病毒性毛细支气管炎与小儿哮喘的T细胞亚群及Th1/Th2功能变化存在相似性,两者发病机制之间存在一定的关联性。Objective To analyze the changes of T cell subsets in children with respiratory syncytial virus infection.Methods Thirty-four children with respiratory syncytial virus infection were served as observation group,and 35 healthy children were simultaneously considered to be in control group.After definite diagnosis,peripheral blood lymphocytes and T lymphocyte subsets of the patients in the two groups were detected.Results The ratios of Th1 and Th2 in observation group were both higher than those of control group （P＜0.05）,while Th1/Th2 was lower in observation group than in control group （P＜0.05）.CD3＋ and CD8＋ subsets of T lymphocytes in peripheral blood were both lower in observation group than in control group （P＜0.05）,while CD4＋ and CD4＋/CD8＋ were both higher in observation group than in control group （both P＜0.05）.Conclusions The changes of T cell subsets and Th1/Th2 in children with respiratory syncytial virus bronchiolitis show similarities with those in children with asthma,which suggest that there is a certain correlation between the pathogenesis of them.

关 键 词：儿童 呼吸道合胞病毒 T细胞亚群 

分 类 号：R373.14[医药卫生—病原生物学]