两亲性壳聚糖衍生物的制备及其负载氧化铁纳米粒子  

Preparation of amphiphilic chitosan derivatives and their application on encapsulation of IO nanoparticles

作　　者：李昆[1] 南海[1] 李亚鹏[2] 席鹏[1] 孙陪陪 王静媛[2] 

机构地区：[1]西安近代化学研究所,西安710065 [2]吉林大学化学学院麦克德尔米德实验室,长春130012

出　　处：《化工新型材料》2013年第11期34-36,52,共4页New Chemical Materials

基　　金：国家自然科学基金(20904014);教育部青年资金(2070310)资助项目

摘　　要：功能性高分子的主链选用壳聚糖,利用西弗碱反应制备了癸基化壳聚糖与具有亲疏水性质的羧甲基化癸基化壳聚糖衍生物。通过疏水相互作用,制备了壳聚糖负载氧化铁复合纳米粒子,复合粒子为超顺磁性,分散良好,尺寸均一,性质稳定,生物相容性好。Alkyl-chitosan derivatives（decyl chitosan）and N-decyl-O, N carboxymethyl chitosan were successfully synthesized with chitosan acting as main chain of the grafted polymers. The water-soluble magnetic composite nanoparticles were achieved by incorporation of iron oxide nanoparticles （IO） inside the polymeric micelle core through hydrophobic in teraction. The vibrating sample magnetometry （VSM）, AFM, TEM, DLS and MTT results indicated that the CMDCTS@ IO composite nanoparticles with narrow size distribution were prepared ,which showed that the nanoparticles had good su- perparamagnetism,good water solubility and low cytotoxicity.

关 键 词：壳聚糖 两亲性 氧化铁 

分 类 号：O631.3[理学—高分子化学]