炎性因子与阿尔茨海默病  

Inflammatory cytokines and Alzheimer's disease

作　　者：侯宛祺 戴雪伶[2,3] 姜招峰[2,3] 

机构地区：[1]首都师范大学生命科学学院,北京100048 [2]北京联合大学生物活性物质与功能食品北京市重点实验室,北京100191 [3]北京联合大学功能食品科学技术研究院,北京100191

出　　处：《生命科学》2013年第11期1071-1076,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31071512);北京市教委科技计划面上项目(KM201211417013)

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是一种老年人易患的中枢神经系统退行性疾病,其主要临床表现为不可逆性、进行性的记忆力衰退,目前发病机制不清。AD患者脑内存在异常高水平的炎性因子及其受体、补体、调节蛋白以及化学因子等免疫炎性的标志物,提示炎性因子可能与AD的发病过程密切相关。综述了近年来有关炎性因子与AD发生发展关系的研究进展。Alzheimer＇s disease （AD） is a neurodegenerative disorder of the central nervous system and predominantly occurs in the elderly, but so far the pathogenesis is still unknown mostly. Previous studies indicate that abnormally high levels of inflammatory cytokines and their receptors, complements and regulatory proteins as well as immune inflammatory markers have been observed in AD brains, suggesting a potential correlation between inflammatory cytokines and AD. Herein in this paper we reviewed the correlation between inflammatory cytokines and the occurrence and development of AD.

关 键 词：阿尔茨海默病 致炎性细胞因子 抗炎性细胞因子 

分 类 号：O51[理学—低温物理] R749.16[理学—物理]