双醋瑞因、硫酸氨基葡萄糖联合玻璃酸钠治疗膝骨关节炎的疗效  

Efficacy of diacerein,glucosamine sulfate and sodium hyaluronate on knee osteoarthritis

作　　者：黄进贤[1,2] 张会昌[1,2] 尹志华[1,2] 罗秀霞[1,2] 叶志中[1,2] 

机构地区：[1]广东医学院附属福田医院香蜜湖风湿病分院 [2]广东医学院风湿病研究所,广东省深圳市518040

出　　处：《实用医学杂志》2013年第22期3749-3751,共3页The Journal of Practical Medicine

基　　金：深圳市医学重点学科建设资助项目(编号:2005C10)

摘　　要：目的:研究双醋瑞因、硫酸氨基葡萄糖联合玻璃酸钠治疗膝骨关节炎的临床疗效。方法:将80例骨关节炎患者随机分为2组,治疗组40例给予双醋瑞因和硫酸氨基葡萄糖片口服12周,同时使用玻璃酸钠注射液膝关节腔内注射,每周1次,连续5周为1个疗程。对照组40例仅予硫酸氨基葡萄糖口服和玻璃酸钠注射液(剂量、疗程同前),观察治疗前后20 m步行痛、关节压痛和WOMAC关节炎指数评分改善情况。结果:12周时两组患者各项指标较治疗前比较差异均具有统计学意义(P均<0.05);治疗组改善程度优于对照组(P<0.05)。治疗过程中,两组患者均未发生严重不良反应。结论:双醋瑞因和硫酸氨基葡萄糖联合玻璃酸钠治疗膝骨关节炎疗效显著,有良好的耐受性和安全性,值得临床推广。Objective To investigate the efficacy of diacerein, glucosamine sulfate and sodium hyaluronate on knee osteoarthritis （KOA）. Methods 80 patients with KOA were randomly divided into 2 groups. 40 cases in observation group received oral diacerein and glucosamine sulfate for 12 weeks, and received intra-articular injection of sodium hyaluronate once a week for 5 weeks. 40 cases in control g;roup only received oral glucosamine sulfate and intra-articular injection of sodium hyaluronate with the same dosage and course. Visual analog scale （VAS） assessment on pain of walking for 20 meters, tenderness on palpation and Western Ontario and McMaster Universities OA （WOMAC） index were evaluated before and after the treatr3ent. Results The assessment indices were significantly improved in both groups after the treatment （P 〈 0.05 ）. and the improvement was more significant in observation group than that in control group （P 〈 0.05）. During the treating process, no severe adverse events were observed in both groups. Conclusions Diacerein, glucosamine sulfate in combination with sodium hyaluronate treatment had prominent effect, was tolerable and safe, and worth clinical promotion.

关 键 词：骨关节炎 双醋瑞因 玻璃酸钠 硫酸氨基葡萄糖 

分 类 号：R684.3[医药卫生—骨科学]