通腑泻热合剂对体外循环患者TNF-α及IL-8的影响  

Influences of Tongfu Xiere Mixture on TNF-α and IL-8 of Patients Undergoing Cardiopulmonary Bypass

作　　者：郭亚雄[1] 林秋伟[1] 张雄[1] 黄丽娜[1] 

机构地区：[1]广州中医药大学第一附属医院心胸血管外科,广东广州510405

出　　处：《新中医》2013年第12期64-67,共4页New Chinese Medicine

基　　金：广东省中医药局科研课题(编号:2010389)

摘　　要：目的:探讨通腑泻热合剂对体外循环患者的肺保护作用。方法:将60例体外循环患者随机分为观察组和对照组各30例,2组均给予常规治疗,观察组加用通腑泻热合剂灌肠治疗,对照组给予等量生理盐水灌肠治疗,观察2组肺部感染及急性呼吸窘迫综合症(ARDS)发生率,同时检测2组肿瘤坏死因子-α(TNF-α)及白细胞介素-8(IL-8)的变化。结果:观察组肺部感染及ARDS发生率分别为6.7%和3.3%,均明显低于对照组的30.0%和13.3%(P<0.05)。观察组在第1、3、5天的TNF-α和IL-8均明显低于对照组(P<0.05)。结论:通腑泻热合剂可降低体外循环患者TNF-α、IL-8的水平,减少肺部感染及ARDS发生率,对体外循环患者具有肺保护作用。Objective： To investigate the pulmonary protective effect of Tongfu Xiere mixture on the pa- tients undergoing cardiopulmonary bypass. Methods.. Sixty patients undergoing cardiopulmonary bypass were equally randomized into observation group and control group. Both groups were given conventional treatment, and the observation group was given enteroclysis with Tongfu Xiere mixture and the control group was given enteroclysis with equivalent volume of physiological saline. The incidences of pulmonary infection and ARDS in the two groups were monitored, and the changes of TNF-α and IL-8 were ob- served in the two groups. Results. The incidences of pulmonary infection and ARDS of the observation group were 6.7% and 3.3% respectively, both significantly lower than those of control group （30.0%, 13.3% respectively; P 〈 0.05）. TNF-α and IL-8 levels of observation group on enteroclysis day 1, 3, 5 were significantly lower than those of control group at the same time points（P 〈 0.05）. Conclusion： Tonfu Xiere mixture can reduce TNF-α and IL-8 levels of patients with cardiopulmonary bypass and reduce the incidence of pulmonary infection and ARDS, showing pulmonary protection of patients undergoing cardiopulmonary bypass.

关 键 词：体外循环 肺保护 通腑泻热合剂(TFXR) TNF-Α IL-8 

分 类 号：R61[医药卫生—外科学]