2型糖尿病合并冠心病血瘀证患者胱抑素C水平与冠状动脉狭窄程度的相关性研究  

Correlation Between Cystatin C and Coronary Artery Stenosis Degree in Type 2 Diabetes Mellitus Patients Complicated with Coronary Artery Disease of Blood-stasis Syndrome

作　　者：朱贤慧[1,2] 

机构地区：[1]南京中医药大学 [2]江苏省中医院,江苏南京210029

出　　处：《新中医》2013年第12期97-99,共3页New Chinese Medicine

摘　　要：目的:探讨血清胱抑素C(CysC)水平与2型糖尿病合并冠心痛血瘀证患者冠状动脉狭窄程度的相关性。方法:将131例经冠状动脉造影检查确诊为冠心痛的2型糖尿病血瘀证患者,应用免疫比浊法检测CysC浓度,采用t检验、秩和检验、双变量相关分析评价2型糖尿病合并冠心病血瘀证患者CysC水平与冠状动脉狭窄程度(Gensini积分)的相关性。结果:CysC阳性组Gensini积分较CysC阴性组升高(P<0.01)。CysC定量分析与Gensini积分双变量相关分析显示,CysC与Gensini积分有明显正相关性(P<0.05)。结论:2型糖尿病合并冠心痛血瘀证患者CysC定性、定量分析与冠状动脉狭窄程度有明显正相关性。Objective： To investigate the correlation between cystatin C and the degree of coronary artery stenosis in type 2 diabetes mellitus（T2DM） patients complicated with coronary artery disease（CAD） of blood-stasis syndrome. Methods. A total of 131 T2DM-CAD patients of blood-stasis syndrome confirmed by coronary angiography received the blood testing of cystatin C with immunoturbidimetry. The cor- relation between cystatin C and Gensini scores of the severity of coronary artery stenosis was analyzed by t-test, rank sum test, and bivariate correlation analysis. Results： The level of Gensini scores in cystatin C positive group was much higher than those in the cystatin C negative group（P〈0.01）. The quantitative analysis revealed that cystatin C was positively correlated with Gensini scores, Cr and UA levels（P〈0.05, P〈0.01）. Conclusion.. The cystatin C level is positively correlated with the degrees of coronary artery stenosis in T2DM-CAM patients with of blood-stasis syndrome.

关 键 词：2型糖尿病 冠心病 动脉粥样硬化 GENSINI积分 胱抑素C(CysC) 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]