不同剂量卡维地洛对急性心肌梗死患者QT、JT离散度及心率变异性的影响  

Effects of Different Doses of Carvedilol on QT,JT Dispersion and Heart Rate Variability in Acute Myocardial Infarction

作　　者：胡晶晶[1] 刘复兴[1] 胡笑容[2] 

机构地区：[1]湖北省钟祥市人民医院 [2]武汉大学人民医院

出　　处：《中西医结合心脑血管病杂志》2013年第11期1313-1315,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究不同剂量卡维地洛对急性心肌梗死患者QT、JT离散度及心率变异性的影响。方法 80例急性心肌梗死患者纳入研究,接受为期3个月的治疗。根据卡维地洛用量将患者随机分均为小剂量组(3.125mg^6.25mg,每天2次)和大剂量组(12.5mg^25mg,每天3次)。治疗前后所有患者均接受长程心电图检查。记录QT、JT离散度及心率变异性的时域、频域指标。所有患者随访半年。结果经过3个月的治疗,两组QT、JT离散度、心率变异性时域及频域指标较治疗前明显改善,大剂量组更为明显(P<0.05)。两组半年内不良心血管事件发生率无统计学意义(P>0.05)。结论与小剂量相比,大剂量卡维地洛能进一步减小急性心肌梗死患者QT、JT离散度,提高慢性心率变异性,但不降低半年内不良心血管事件。Objective To explore the effects of different doses of carvedilol for improving QT,JT dispersion and heart rate varia- bility（HRV） in patients with acute myocardial infarction （AMI）. Methods One hundred and twenty patients with AMI were enrolled in this study and were treated for 4 months. They were divided into 2 groups according to the dose of carvedilol：Low- close group （3.25 mg to 6.25 mg,Bid,n=40） and high - dose group（12.5 mg to 25.0 mg,Bid,n=40）. Before and after treatment,all patients received Hoiter examination. QT,JT dispersion and HRV parameters were recorded. All patients were followed up to 6 months. Results After three months of treatment,compared to the before, the HRV in the time domain and frequency domain indicators of all petients were improved,so were the QT,JT dispersion. But the high- dose group was more effective（P〈0.05）. There were no differences for ad- verse cardiovascular event rates between two groups（P〈0.05）. Conclusion Compared with the low - dose carvedilol,the high - dose was better in improving QT,JT dispersion and HRV in AMI patients,but not reducing the rate of adverse cardiovascular event.

关 键 词：急性心肌梗死 卡维地洛 QT离散度 JT离散度 心率变异性 

分 类 号：R542.22[医药卫生—心血管疾病]