碳酸钙包覆光敏药物叶绿素的制备  

Preparation of CaCO_3-encapsulated Photosensitive Drug ChlorophyⅡ

作　　者：武美霞[1] 高艳丽[1] 韩璇[1] 郭永[1] 

机构地区：[1]山西大同大学化学与化工学院,山西大同037009

出　　处：《山西大同大学学报（自然科学版）》2013年第5期48-50,共3页Journal of Shanxi Datong University(Natural Science Edition)

基　　金：国家自然科学基金[21073113];山西省高等学校大学生创新创业项目[2011274];山西大同大学教研重点项目[XJY-2013110];山西大同大学博士科研启动基金[2008-B-19]

摘　　要：采用一步共沉淀法制备了包覆光敏药物叶绿素的CaCO3粒子,利用扫描电子显微镜(SEM)对所制粒子的微观形貌进行了表征。用紫外和荧光光谱仪测试了叶绿素乙醇溶液的光谱谱图,其紫外光谱最大吸收波长分别为431,662nm,其荧光光谱的激发和发射最大波长分别为664,672nm。用紫外分光光度计测定总药量和游离的光敏药物叶绿素,并计算其包封率。结果表明,叶绿素质量浓度为0.025g/mL时其包封率达95%。CaCO3 particles doped by photosensitive drug chlorophyll were prepared through an one-pot approach using the CaCl2 and NaHCO3 as substrate and chlorophyll as photosensitive model drug. The resulting chlorophyll in ethanol solution was characterized by UV and fluorescence spectrophtotmeter. The maximum absorption wavelength of UV spectra of chlorophyll were 431 nm and 662 nm. In the spectrum of the fluorescence spectra, maximum wavelength of excitation and emission of chlorophyll were 664 nm and 672 nm. To calculate the encapsulation efficiency, total and free photosensitive drug chlorophyll was assayed by UV spectrophotometer. With the increase of the concentration of chlorophyll the encapsulation efficiency decreased. Encapsulation efficiency of 0.025 mg· L^-1 chlorophyll solution using CaCO3 particles was up to 95%.

关 键 词：光敏药物 叶绿素 碳酸钙 包封率 

分 类 号：O643.3[理学—物理化学]