生物医用PLA改性研究进展  

A Review of Biomedical Poly(lactic acid) Modification Research Progress

作　　者：夏学莲[1] 刘文涛[1] 王利娜[1] 何素芹[1] 朱诚身[1] 

机构地区：[1]郑州大学材料科学与工程学院,郑州450052

出　　处：《高分子通报》2013年第11期29-38,共10页Polymer Bulletin

摘　　要：聚乳酸(polylactic acid)材料是一种用途广泛的可生物降解高分子材料,已经成为生物医用材料中最受重视的材料之一。但是聚乳酸也存在许多缺陷,限制了其在医药领域的广泛应用。本文综述了聚乳酸疏水性强、细胞亲和性差、力学性能不足,降解产物造成局部酸性积累而导致机体发生无菌性炎症反应,缺乏修复、降解、吸收速度与细胞的增殖、组织修复速度匹配的系列产品,成本高,均聚物成孔性能差等缺陷,总结了近些年国内外针对以上各个缺陷做出的改进方案,并对聚乳酸医用改性的研究发展方向进行了展望。Polylactic acid （PLA） is at present one of the most promising biodegradable polymers and has a wide range of applications. It has become one of the most important biomedical materials. But the PLA also has many disadvantages, which limits its application in the medicine field. In this paper, the strong hydrophobicity, poor cellular affinity, poor mechanical properties, aseptic inflammation reaction resulted from local accumulation of lactic acid produced by degradation products, lacking series products whose repair, degradation and absorption speed cannot well matched their cell proliferation and tissue repair speed, high cost, poor hole forming performance of homopolymer are reviewed. Summarized the scheme at home and abroad in recent years in view of the above various defects made, and the direction of research and development of PLA medical modification are discussed. Besides, the improvements made in recent years for each of the above defects are summarized. At last, the research and development orientation on PLA medical modification are prospected.

关 键 词：聚乳酸 生物医用材料 改性 

分 类 号：R318.08[医药卫生—生物医学工程]