重度慢性阻塞性肺疾病患者稳定期不同治疗方案的比较  

Comparison of the Effect Among Different Therapeutic Regimens for Severe COPD Patients in Stable Phase

作　　者：刘华[1] 谢梓正[1] 

机构地区：[1]广东药学院附属第一医院内二科,广东广州510080

出　　处：《武汉大学学报（医学版）》2013年第5期770-772,776,共4页Medical Journal of Wuhan University

基　　金：广东省自然科学基金资助项目(编号:S2011010002100)

摘　　要：目的:分析稳定期重度慢性阻塞性肺疾病(COPD)的患者对沙美特罗/氟替卡松、噻托溴铵吸入治疗和口服茶碱治疗的效果。方法:137个患者随机分配接受沙美特罗/氟替卡松50μg/250μg吸入,bid,或者噻托溴铵18μg吸入,qd,或者口服缓释茶碱0.2g,bid,并进行测试。结果:3组患者分别完成试验,结果显示3组患者之间的肺功能、6min步行实验、BODE指数、痰VEGF结果都有所改善,结果有统计学差异(P<0.05)。结论:噻托溴铵组、沙美特罗/氟替卡松组和茶碱组对于重度稳定期COPD患者均有较好的疗效,而前两组相对于茶碱组疗效更显著,噻托溴铵组可能对于气道重塑有潜在的影响。Objective： To analyze the effect of salmeterol/fluticasone inhalation, tiotropium bromide in- halation, and oral theophylline treatment on chronic obstructive pulmonary disease （COPD） pa tients in stable phase. Methods： A total of 137 patients received different treatment randomly and respectively as salmeterol/fluticasone inhalation （50μg/250μg, bid）, tiotropium bromide inhala- tion （18μg, qd）, and oral sustained-release theophylline （0.2 g bid）, pulmonary function test, 6 minutes walk test, and BODE index scoring were adopted to evaluate the therapeutic effect. Results： All patients were completed tests and showed improvement after different treatment （all P〈0. 05）, and tiotropium and salmeterol/fluticasone showed better effect than theophylline. Conclusion： All the three therapeutic regimens, especially salmeterol/fluticasone or tiotropium bromide inhalation, were effective for severe COPD patients in stable phase, while tiotropium bromide inhalation might have potential effects on airway remodeling.

关 键 词：稳定期COPD 布地奈德 福莫特罗 噻托溴铵 茶碱 肺功能 

分 类 号：R563[医药卫生—呼吸系统]