育龄女性血清硫酸脱氢表雄酮(DHEA-S)检测分析及其临床意义  

Detection of Serum Dehydroepiandrosterone Sulfate(DHEA-S) Levels in Reproductive Women and Its Clinical Significance

作　　者：叶雅萍[1] 欧奇志[2] 覃爱平[2] 

机构地区：[1]广西医科大学研究生学院,南宁530021 [2]广西医科大学第一附属医院生殖医学研究中心,南宁530021

出　　处：《生殖与避孕》2013年第11期755-759,共5页Reproduction and Contraception

基　　金：国家自然科学基金项目;项目编号:81260096

摘　　要：目的：探讨月经正常的不同年龄段育龄女性血清硫酸脱氢表雄酮（DHEA—s）水平变化及其临床应用意义。方法：l156名月经正常且年龄在21～45周岁的育龄女性为研究对象，按年龄分成5组，检测血清DHEA．S、bFSH、bLH及窦卵泡计数（AFC）水平。结果：年龄段在21～25岁、26～30岁、31～35岁、36～40岁、41～45岁妇女的血清DHEA—S90％正常参考值范围分别为3．42～lO．42gmol／ml、3．27-10．20gmol／ml、2．59~10．14gmol／ml、2．26--8．08gmol／ml、2．14-7．50gmol／ml。不同年龄组间血清DHEA—S水平比较差异有统计学意义（P〈0．01），血清DHEA—S与年龄呈负相关，差异有统计学意义（P〈0．28，95％CI=5．78～6．03，P〈O．01）；血清DHEA—s与bFSH和bFSH／LH均呈负相关，DHEA—S与AFC呈正相关，差异均有统计学意义，r分别为-0．13、～0．08、0．592，95％C1分别为7．53～7．89、1．67～1．82、13．90～14．93，P〈0．01。结论：随年龄增大，血清DHEA．S水平下降，可作为评估卵巢储备功能的一项参考指标，为临床诊治提供参考。Objective： To explore serum dehydroepiandrosterone sulfate （DHEA-S） concentrations in reproductive women of different age with regular menstruation and its clinical significance. Methods： Totally 1 156 reproductive women aged 21-45 years old were enrolled. Subjects were divided into five groups by age, antral follicular count （AFC） and serum levels of DHEA-S, bFSH, bLH were detected. Results： The 90% normal reference value range of DHEA-S was 3.42-10.42 μmol/ml in group of age from 21 to 25 years old, 3.27- 10.20 μmol/ml in group of age from 26 to 30 years old, 2.59-10.14 μmol/ml in group of age from 31 to 35 years old, 2.26-8.08 μmol/ml in group of age from 36 to 40 years old, 2.14-7.50 μmol/ml in group of age from 41 to 45 years old. The serum DHEA-S levels between different age groups had significant differences （P〈0.01）. The serum DHEA-S level was negatively correlated with age （r=-0.28, 95%CI=5.78-6.03, P〈0.01）. In addition, there was a negative correlation between DHEA-S and bFSH, bFSH/LH （r=-0.13, 95%CI=7.53-7.89; r=-0.08, 95%CI=1.67-1.82, P〈0.01）, and a positive correlation between DHEA-S and AFC （r=0.592, 95%CI=13.90-14.93, P〈0.01）, the differences were statistically significant. Conclusion： As the age increased, serum DHEA-S levels decreased. Serum DHEA-S levels can be used as an indicator to evaluate the ovarian reserve function, and provide reference for clinical medication.

关 键 词：硫酸脱氢表雄酮(DHEA—S) 90%正常参考值 基础卵泡刺激素(bFSH) 基础卵泡刺激素 黄体生成素(bFSH bLH) 窦卵泡计数(AFC) 

分 类 号：R711[医药卫生—妇产科学] R446.1[医药卫生—临床医学]