氟比洛芬酯对TUR-P术后膀胱痉挛性疼痛治疗效果的观察  

Clinical observation on analgesic effect of flurbiprofen for spastic pain after TUR-P

作　　者：张南晖[1] 郭时英[1] 刘龙[1] 

机构地区：[1]沈阳军区总医院泌尿外科,辽宁沈阳110016

出　　处：《局解手术学杂志》2013年第6期625-626,628,共3页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的观察氟比洛芬酯注射液对经尿道前列腺电切术(TUR-P)后膀胱痉挛性疼痛的治疗效果及其不良反应。方法将40名良性前列腺增生并将进行TUR-P术的患者随机分成观察组(n=20)和对照组(n=20)。术后患者出现膀胱痉挛性疼痛时,观察组患者使用100 mg氟比洛芬酯配比500 mL生理盐水静脉滴注,若有需要,可加药静脉续滴;对照组患者肌肉注射盐酸哌替啶100 mg,若效果不理想则肌肉注射盐酸布桂嗪100 mg,于用药后30 min,1 h,2 h,4 h,6 h,8 h对2组患者进行视觉模拟评分(VAS),观察并记录用药后副作用及并发症的发生情况。结果观察组和对照组患者在给药后30 min、1 h、2 h的VAS评分无显著差异(P>0.05);用药后4 h、6 h、8 h的视觉模拟评分观察组明显低于对照组,在口干、眩晕、恶心、呕吐等不良反应发生率方面观察组也明显低于对照组,具有统计学差异(P<0.05)。2组患者在继发性出血方面则无显著差异(P>0.05)。结论静脉滴注氟比洛芬酯可作为治疗TUR-P术后膀胱痉挛性疼痛的理想方法。Objective To observe the analgesic effect and its complications of flurbiprofen axetil for spastic pain after transurethral re-section of prostate （TUR-P）. Methods 40 patients who were clinically diagnosed as benign prostatic hyperplasia and underwent TUR-P were randomly divided into the experimental group （n = 20）and the control group （n = 20）. When the postsurgical spastic bladder pain happened, the patients in the experimental group received intravenous drip of flurbiprofen axetil 100 mg with saline 500 mL,and the patients in the con- trol group received intramuscular injection of pethidine hydrochloride 100 mg. If its effect is not good, 100 mg bucinnazine hydrochloride were injected. Analgesia efficacy was assessed by visual analog scales（VAS） at 30 min, 1 h,2 h,4 h,6 h and 8 h after medication. At the same time ,the side-effects and complications were observed and recorded. Results There is no statistical difference between the experimental group and the control group at 30 min,1 h, and 2 h after medication（P 〉0.05） ,but at 4 h,6 h and 8 h after medication,VAS score of the experimental group is obviously lower than that of the control group （ P 〈 0.05 ）. And the incidence of adverse reaction of the experimental group, such as thirst, dizziness, nausea and emesia, was lower than that of the control group （P 〈 0.05 ）. But there is no significant difference in incidence of the secondary bleeding between the two groups （ P 〉 0.05 ）. Conclusion Intravenous drip of flurbiprofen axetil can be an ef-fective and safe way of curing postsurgical spastic bladder pain after TUR-P.

关 键 词：膀胱痉挛 氟比洛芬酯 经尿道前列腺电切术 

分 类 号：R605[医药卫生—外科学]