子宫内膜异位症不孕患者腹腔镜术后应用GnRH-a对妊娠的影响  

GnRH-a Effect on Pregnancy of Infertile Patients with Endometriosis after Laparoscopic Surgery

作　　者：吴艳霞[1] 杨红玉[1] 常春[1] 

机构地区：[1]解放军白求恩国际和平医院妇产科,石家庄050082

出　　处：《临床误诊误治》2013年第11期68-70,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的观察子宫内膜异位症(endometriosis,EM)不孕患者腹腔镜术后应用促性腺激素释放激素激动剂(gonadotropin releasing hormone agonist,GnRH-a)的妊娠情况。方法选取2009年6月—2012年6月我院行腹腔镜治疗的EM不孕65例,按自愿原则分为观察组35例和对照组30例,观察组于腹腔镜术后予GnRH-a治疗3个月,对照组术后予期待治疗。观察两组治疗效果和自然妊娠率。结果随访12个月,观察组完全缓解率及自然妊娠率均高于对照组,复发率低于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论对于有生育要求的EM患者腹腔镜术后应用GnRH-a治疗可提高完全缓解率及自然妊娠率,并降低复发率。Objective To observe effectiveness of gonadotropin releasing hormone agonist （GnRH-a） on pregnancy of infertile patients with endometriosis （EM） after laparoscopic surgery.Methods A total of 65 infertile patients with EM,who had undergone laparoscopic surgery in our hospital during June 2009 and June 2012,were divided into observation group （n =35） and control group （n =30） according to the voluntary principle.After laparoscopic surgery,the observation group was treated with GnRH-a for 3 months,while the control group was treated with expectation.The treatment effectiveness and natural pregnancy rate in the two groups were analyzed.Results A 12-month follow-up showed that the complete remission rate and natural pregnancy rate in observation group were higher than those in control group,while the recurrence rate was lower than that in control group,and the differences were statistically significant （P ＜ 0.05 or P ＜ 0.01）.Conclusion The GnRH-a application can improve the complete remission and natural pregnancy rates,and reduce the recurrence rate of infertile patients with EM after laparoscopic surgery.

关 键 词：腹腔镜 子宫内膜异位症 不孕 促性腺激素释放激素激动剂 妊娠结局 

分 类 号：R711.71[医药卫生—妇产科学]