Eupergit手性配体交换色谱固定相的制备及应用  

Preparation of a Eupergit Chromatographic Stationary Phase and its application

作　　者：丁然 Van bracht. Hendrik Stock. Elke Thomas-Helmut Scheper Danneel. Hans-Jürgen 

机构地区：[1]德国北威州利普高校应用生物化学实验室,代特莫尔德32756

出　　处：《山西化工》2013年第5期1-5,共5页Shanxi Chemical Industry

摘　　要：介绍了以Eupergit C 250L为载体,L-羟脯氨酸盐为手性配体,通过两者间的"一步交联反应",制备出一种新型的Eupergit手性配体交换固定相。交联反应过程简单、高效、副反应少。尝试通过此大颗粒的Eupergit手性配体固定相对丝氨酸手性对映异构体进行拆分,得到了良好的拆分结果。为将来在工业领域内,通过使用制备型拆分柱来拆分手性氨基酸的设想提供了有利的技术支持。This study introduced the preparation of a new type Eupergit chiral ligand exchange stationary phase by using Eupergit C 250L as a carrier, L-hydroxyproline salt as a chiral ligand and one-step-crosslinking reaction between them. This is a simple and high efficient synthesis process with less byproduct in reaction. In the process, chiral serin was splitted with large particles of Eupergit chiral ligand stationary phase and the splitting result is good. The study could provide a technical basis for the future industrial trials of splitting chiral amino acids with preparative split column

关 键 词：Eupergit(R)C 250L 手性固定相 配体交换色谱 对映体分离 

分 类 号：TQ21[化学工程—有机化工]