109例药品不良反应报告回顾性分析  

The retrospective analysis of 109 cases ADR report

作　　者：王建青[1] 李俊[2] 吕雄文[2] 刘丽萍[1] 

机构地区：[1]安徽医科大学第二附属医院药学部,安徽合肥230601 [2]安徽医科大学药学院,安徽合肥230032

出　　处：《安徽医药》2013年第11期1993-1995,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省自然科学基金(No 1208085QH143);安徽医科大学中青年学术骨干资助基金

摘　　要：目的了解该院药品不良反应(ADR)发生的特点及规律,以进一步促进临床合理用药。方法分别从报告人、患者情况、引发ADR的药品种类、给药途径、ADR涉及器官或系统以及临床表现等方面对某院2011年1月—2012年6月收集上报的109例ADR报告进行了统计分析。结果 109例ADR报告中,女性(61.47%)多于男性(38.53%),60岁以上患者ADR发生率最高,占23.85%;以口服给药方式引起的ADR居多,占57.8%;抗感染药物、心血管系统药物以及中药制剂分别位列前三位;临床表现以胃肠道系统损害最为常见。结论应重视ADR的监测与报告,积极改进措施,减少不良反应漏报,促进临床规范合理用药。Objective To study the characteristics and regularity of adverse drug reactions （ADR）occurred in our hospital and promote rational use of drugs in clinic. Methods All of 109 ADR cases collected from 2011.1 - 2012.6 in our hospital were analyzed statistical- ly in respect of the reporters, sex and age of patients, drug categories, routes of administration, organs and systems involved and clinical manifestations. Results Of the 109 ADR cases, women patients（61.47 % ） was reported more than men（38.53 % ）, 23.85% oc- curred in patients aged above 60, 57.8% of cases were orally treated, the highest proportion occurred in patients was induced by anti-in- fective drugs, cardiovascular drugs and the traditional Chinese medicines. The most common clinical manifestation was the damages of gastrointestinal system. Conclusion ADR monitoring and reporting should be paid great attention and strengthened by promotion of measurement and reducing missing report rate of ADR, in order to ensure standard and rational drug use in the clinic.

关 键 词：药品不良反应 报告 分析 监测 

分 类 号：R95[医药卫生—药学]