2-噻吩乙胺合成新工艺  

New Synthesis Process of 2-Thiopheneethylamine

作　　者：邢俊德[1] 宋志勇[1] 苗茂谦[2] 卢建军[2] 张照昱[1] 

机构地区：[1]太原理工大学化学化工学院,山西太原030024 [2]太原理工大学教育部与山西省煤科学与技术重点实验室,山西太原030024

出　　处：《化学世界》2013年第11期663-665,共3页Chemical World

摘　　要：2-噻吩乙醇用SiO2负载的PCC(氯铬酸吡啶)氧化得2-噻吩乙醛,不经提纯,进一步与盐酸羟胺反应得2-噻吩乙醛肟,最后经NaBH4/CuSO4)/amberlyst-15还原得2-噻吩乙胺,总收率76.5%。2-Thienylacetaldehyde was synthesised by oxidation of 2-thienylethanol with PCC（Pyridinium chlorochromate）/SiO2, without purification and was further converted to 2-thienylacetaldoxime through reaction with hydroxylamine hydrochloride. Finally, 2-thiopheneethylamine was obtained by the reduction of 2-thienylacetaldoxime with NaBH4-CuSO4-amberlyst-15. The overall yield of this process for 2-thio- pheneethylamine was about 76.5%.

关 键 词：2-噻吩乙胺 合成 2-噻吩乙醇 2-噻吩乙醛 2-噻吩乙醛肟 

分 类 号：O622.6[理学—有机化学]