胰岛素样生长因子-1与糖尿病慢性并发症  

Insulin-like growth factor-1 and diabetic chronic complications

作　　者：杨巧[1] 张莉[1] 刘霞[1] 黄薇[1] 夏丽[1] 肖谦[1] 

机构地区：[1]重庆医科大学附属第一医院老年病科内分泌代谢学组,400016

出　　处：《国际内分泌代谢杂志》2013年第6期415-418,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81170752）;重庆市卫生局重点项目（2010-1-8）;重庆市自然科学基金资助项目（CSCT,2010BB5396）

摘　　要：胰岛素生长因子-1（IGF-1）是一种结构与功能都与胰岛素类似的蛋白多肽.IGF-1广泛存在于机体各组织中,参与机体多种生理、病理过程.IGF-l通过多条途径影响糖尿病心、脑、肾、神经等慢性并发症的发生、发展.研究其作用机制将为糖尿病慢性并发症的治疗提供新的思路.Insulin-like growth factor-1 （IGF-1） is a kind of protein polypeptide which widely exists in the body tissue and its structure and functions are similar to insulin.IGF-1 involves in many pathological and physiological process.Through a variety of ways,IGF-1 affects the occurrence and development of heart,brain,kidney,nerves and other chronic complications of diabetes.Exploring the mechanism of IGF-1 provides new ideas for the treatment of diabetic chronic complications.

关 键 词：胰岛素样生长因子-1 糖尿病 慢性并发症 

分 类 号：R587.2[医药卫生—内分泌]