冠心病患者血清中HB-EGF、TGF-β_1的表达  

The Expression of HB-EGF,TGF-β_1 in the Serum of Patients with Coronary Heart Disease

作　　者：刘一剑[1] 谭祖松[1] 邓晋[1] 黄珲[1] 冯宏达[1] 谢哲[1] 游咏[1] 

机构地区：[1]南华大学医学院,湖南衡阳4221001

出　　处：《中国医学创新》2013年第31期1-4,共4页Medical Innovation of China

基　　金：湖南省大学生研究性学习和创新性实验计划项目(2011-200)

摘　　要：目的:探讨冠心病患者血液中肝素结合表皮生长因子(HB-EGF)及转化生长因子β1(TGF-β1)mRNA的表达水平及临床意义。方法:检测30例急性冠脉综合征(ACS组)、30例稳定性心绞痛组(SAP组)及20例正常对照组(NC组)患者血清中HB-EGF、TGF-β1mRNA的表达水平,比较各组间的差异,并分析影响HB-EGF、TGF-β1mRNA表达水平的相关性因素,探讨其与HB-EGF、TGF-β1的关系。结果:CHD组患者中HB-EGF mRNA明显高于NC组(P<0.05),ACS组患者中HB-EGF mRNA亦明显高于SAP组(P<0.05);而TGF-β1mRNA在血液中表达反之:CHD组患者中TGF-β1mRNA明显低于NC组(P<0.05),ACS组患者中TGF-β1mRNA亦明显低于SAP组(P<0.05)。体重指数、血糖、总胆固醇、甘油三酯、低密度脂蛋白及高密度脂蛋白与HB-EGF mRNA及TGF-β1mRNA表达高低无明显相关关系。结论:体重指数、血糖、血脂与HB-EGF mRNA及TGF-β1mRNA表达无明显相关,HB-EGF的升高在冠心病的发生、发展过程中可能作为一个独立危险因子存在,而TGF-β1则可能在冠心病AS病变中有一定保护作用。Objective： To investigate the serum level of Heparin Binding Epidermal Growth Factor like Growth Factor （ HB-EGF ） and Transforming Growth Factor-β1（ TGF-β1） in patients with coronary heart disease （ CHD ） and its clinical significance. Method： Serum levels of HB- EGF mRNA and TGFβ1 mRNA in patients with acute coronary syndrome （ ACS group, n=30 ）, stable angina pectoris （ SAP group, n=30 ）, and normal control subjects （ NC group, n=20 ） were measured by RT-PCR.The differences of three groups were compared.The correlation factors with the serum level of HB-EGF, TGFβ1 mRNA were analyzed.Result： The serum HB-EGF mRNA level of the CHD group （ 0.69 ± 0.09 ）, it was significantly higher than the normal control group （ NC group ） （ 0.63 ± 0.06 ） （ P〈0.05 ） .The serum HB-EGF mRNA level of ACS group was （ 0.71 ±0. 10 ）, it was significantly higher than the SAP group （ 0.67 ± 0.07 ） （ P〈0.05 ） .The serum TGF- 13 1 mRNA level was just opposite to the serum HB-EGF mRNA.The serum TGFβ1 mRNA of the CHD group was （ 1.02 ± 0.08 ）, it was significantly less than the NC group （ 1.08 ± 0.08 ） （ P〈0.05 ） .The serum TGFβ1 mRNA level of the ACS group was （ 1.00 ± 0.08 ）, it was significantly less than the SAP group （ 1.04 ± 0.08 ） （ P〈0.05 ） .Body weight index and blood glucose and blood lipid were not related to The serum HB-EGF and TGFβ1 mRNA level.Conclusion： Body weight index and blood glucose and blood lipid were not related to The serum HB-EGF arid TGFβ1 mRNA level.The high level of HB-EGF may be a independent risk factor of CHD.TGFβ1 may have a protective effect for the development process of atherosclerosis.

关 键 词：肝素结合表皮生长因子 转化生长因子-Β1 冠心病 急性冠脉综合征 稳定性心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]