奶牛子宫内膜炎免疫调控研究进展  

Progress on Immune Regulation of Cow Endometritis

作　　者：胡广胜[1] 王旭荣[1] 杨峰[1] 陈炅然[1] 苗小楼[1] 王玲[1] 罗金印[1] 李新圃[1] 李宏胜[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,农业部兽用药物创制重点实验室,甘肃省新兽药工程重点实验室,甘肃兰州730050

出　　处：《动物医学进展》2013年第11期92-96,共5页Progress In Veterinary Medicine

基　　金：兰州市科技计划(2011-1-70);甘肃省国际合作项目(1204WCGA019)

摘　　要：奶牛子宫内膜炎是造成奶牛不孕的主要原因之一,严重影响奶牛业的发展。奶牛子宫内膜炎炎症发展过程中,多种因素对奶牛子宫的免疫调节均有不同程度的影响。奶牛子宫内的免疫防御机制主要是通过细胞免疫和体液免疫在起作用,其作用过程主要是通过子宫的特异性免疫和非特异性免疫在发挥作用。目前对奶牛子宫炎具有免疫调控作用的物质主要有细胞因子、激素、天然产物及抗原等,这些物质通过刺激奶牛机体的免疫应答,或者提高机体的免疫力而对奶牛子宫的炎症起到调理作用。论文从不同角度、不同层面对奶牛子宫内膜炎免疫机制及免疫调控进行了综述,对于奶牛子宫内膜炎进一步深入研究,研发预防和治疗该病的新型免疫制剂及疫苗提供参考。Cow endometritis is considered to be one of the important factors of infertility w hich blocked the development of dairy industry .The immunoregulation of uterus is affected by many factors at different de-gree during the course of endometritis development .The main immune defense mechanisms of uterus in cows include cell-mediated immunity and humoral immunity which work through specific immunity and non-specific immunity ,respectively .At the present ,it is reported that immunoregulation substances （cy-tokines ,hormone ,natural product and antigen et al ） could stimulate immune response or enhance immuni-ty of cow to regulate inflammation in cow uterus .This paper summarized immunologic mechanisms and immunoregulation involved cow endometritis ,which will be the foundation for further study of this disease and guideline of the new immune preparations and vaccines to prevent and cure cow endometritis .

关 键 词：奶牛子宫内膜炎 免疫机制 免疫防御 免疫调控 

分 类 号：S857.22[农业科学—临床兽医学]