氯胺酮相关性膀胱炎的临床分析及治疗  

The clinical survey and synthetical therapy of ketamine-associated cystitis

作　　者：王宇雄[1,2] 刘春晓[1] 姜成龙 谢小平 

机构地区：[1]南方医科大学珠江医院泌尿外科,广州510282 [2]广东省中西医结合医院泌尿外科,广东佛山528200

出　　处：《重庆医学》2013年第32期3911-3912,3915,共3页Chongqing medicine

基　　金：广东省中医药管理局科研基金资助项目(20111147)

摘　　要：目的探讨氯胺酮相关性膀胱炎的临床表现、诊断及其治疗方法的有效性。方法回顾性地分析了2008年3月至2013年3月该院收治的氯胺酮相关性膀胱炎患者21例,其中男16例,女5例。采取O′Leary-Sant评分及其尿流动力学检查的方法对水扩张治疗前后疗效进行比较。结果经过水扩等综合治疗后,平均随访(8±4)个月,21例患者O′Leary-Sant症状和问题评分明显降低,膀胱容量增加,逼尿肌不稳定收缩频率减少。结论长期吸食氯胺酮可导致严重的下尿路症状,以尿频、尿急为主,严重者有膀胱挛缩。而麻醉状态下水扩张能显著地增加膀胱容量,配合膀胱灌注等综合治疗,可有效地治疗氯胺酮相关性膀胱炎。Objective To investigate the clinical symptoms and diagnosis of ketamine-associated cystitis,and evaluate the effec- tiveness of treatment. Methods From march 2008 to march 2013,21 cases of patients（16 males and 5 females）were respectively studied. And O＇leary-sant scores and urodynamic index were taken to analysis. Results After comprehensive treatment of hydrodis- tention,the Orleary-sant scores and frequency of unstable detrusor contraction were decreased,and the maximum bladder capacity was expanded among 21 patients with average follow-up time of 8-1-4 months. Conclusion Long-term ketamine abuse can cause se- vere lower urinary tract symptoms,such as urinary frequency, urgency and more severe cases of bladder contracture. However, the hydrodistention can significantly increase bladder capacity under anesthesia with intravesical instillation.

关 键 词：氯胺酮 膀胱炎 症状 治疗 

分 类 号：R595.3[医药卫生—内科学] R694[医药卫生—临床医学]