猪繁殖与呼吸综合征免疫防制新途径的研究进展  

Research Progress on New Ways of Immune Prevention and Control of Porcine Reproductive and Respiratory Syndrome

作　　者：欧小兵[1] 车晨[1] 李涵依[1] 全亚玲[1] 戴静[1] 郝葆青[1] 

机构地区：[1]西南民族大学生命科学与技术学院,四川成都610041

出　　处：《中国畜牧兽医》2013年第11期168-174,共7页China Animal Husbandry & Veterinary Medicine

基　　金：西南民族大学研究生"创新型科研项目"(CX2013SP82)

摘　　要：猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是一种主要表现为母猪繁殖障碍与仔猪呼吸道症状的传染病。近年来,猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)变异株不断出现,免疫逃避及持续性感染使得猪群发病率或复发率均相继增高,给养猪业带来了巨大的损失。目前所采用的胃肠道途径接种活疫苗或灭活疫苗的方法无法诱导对猪群的全面保护作用。为减少养猪业的经济损失,亟需研制新防制方法和新疫苗接种途径。作者主要从黏膜免疫的免疫部位、呼吸道保护性黏膜免疫反应诱导、黏膜免疫途径、佐剂的选择及病毒的免疫抑制反应等方面简要论述了有效防制PRRSV的黏膜免疫方法的研究进展,为进一步了解黏膜免疫抵御PRRSV突变株感染及黏膜疫苗研制等方面提供有用的信息。Porcine reproductive and respiratory syndrome （PRRS） was one of infectious disease, its main manifestations were reproductive disorders in sows and respiratory symptoms in piglets. Due to constantly emerging of porcine reproductive and respiratory syndrome virus （PRRSV） variant, and enable virus to evade immune surveillance, which had brought huge challenges to the swine industry. The inoculation of gastrointestinal way with live or inactivated PRRS vaccine was ineffective in inducing complete protection to the swine herds. In order to reduce the economic losses in the swine industry, new control methods and design of new vaccine approaches should be figured out soon. The research progress on the effective prevention and treatment of PRRSV with mucosal immune method was discussed briefly in this review. The mucosal immunity including mucosal sites, respiratory protective mucosal immune response was introduced, selection of mucosal immune route and adju- vant as well as the immunosuppression were elaborated. This information mightbe a help in understanding the mucosal immu- nity against PRRSV variants and designing innovative mucosal vaccines.

关 键 词：黏膜免疫 猪繁殖与呼吸综合征病毒 免疫抑制 保护性免疫反应 佐剂 

分 类 号：S852.65[农业科学—基础兽医学]