血清尿酸水平和左房内径与老年人房颤的相关性研究  

Study of the correlation between serum uric acid level,left atrial diameter and atrial fibrillation in elderly patients

作　　者：杨旭[1] 白丽[1] 王翠英[1] 孙颖[1] 秦明照[2] 李敏[1] 

机构地区：[1]首都医科大学附属北京友谊医院医疗保健中心,北京100050 [2]首都医科大学附属北京同仁医院干部医疗科,北京100730

出　　处：《临床和实验医学杂志》2013年第21期1717-1720,共4页Journal of Clinical and Experimental Medicine

基　　金：北京市科委资助项目1.<老年心房颤动患者规范化抗凝治疗的研究>Z111107067311028;2011-9~2014-9;2.超声二维斑点追踪技术评价老年射血分数正常心衰患者的左室功能。No.11JL29

摘　　要：目的观察老年人房颤与血尿酸水平、左房大小的关系,并分析这一关系的临床意义。方法选择2012年4月至2013年3月住院的房颤患者89例作为房颤研究组,同期住院窦性心律患者85例作为非房颤对照组。记录各组一般资料及超声心动图、血生化水平。用Logistic回归分析房颤发生的危险因素。结果单因素分析结果显示,房颤研究组与非房颤对照组相比,年龄较大(P<0.017),超声心动测量左房内径偏大(P<0.001),左室射血分数较低(P<0.001),血肌酐(P=0.003)、尿酸(P=0.001)、尿素氮(P<0.001)均增高。Logistic回归分析显示,尿酸水平和左心房内径是房颤发生的独立危险因素,与房颤的发生存在显著的关系。结论血尿酸水平和左心房大小与老年患者房颤的发生密切相关。Objective The association between serum uric acid （SUA） level and atrial fibrillation （AF） in elderly is currently poorly known. We examined the association between SUA level, left atrial diameter （LAD） and risk of incident AF in elder patients. Methods A total of 89 patients with AF and 85 healthy subjects were consecutively enrolled in this study. The baseline clinical data were collected. SUA level was measured. LAD was determined by echocardiography. Risk factors of AF were analyzed by univariate or multivariate logistic regression analysis. Results The age, SUA level, serum creatinine and BUN level and LAD were significantly higher in AF group. Multivariate logistic regression a- nalysis showed SUA level and LAD were independent risk factors for AF in eider patient. Conclusion Elevated SUA level and larger LAD may be risk factors for the development of AF in elder patients.

关 键 词：老年人 心房颤动 尿酸 左心房内径 氧化应激 

分 类 号：R541.75[医药卫生—心血管疾病]